Miscellaneous Infectious Diseases

Molecular diagnosis of bovine B-cell lymphoma using polymerase chain reaction for immunoglobulin heavy chain gene

“…Lymphoma is one of the most common neoplasms in cattle, and enlargement of superficial lymph nodes is an important clinical finding that can lead to the suspicion of bovine lymphoma [1,8]. Cytology of enlarged superficial lymph nodes obtained by fineneedle aspiration (FNA) are used for definitive diagnosis of bovine lymphoma [10].…”

Disseminated thymic B-cell lymphoma in a Holstein heifer

“…2,10,29 SBL usually affects cattle <3 y old; EBL usually affects those >3 y old. 2,29 In the calf or juvenile form, sudden onset of lymphoid hyperplasia, weight loss, fever, tachycardia, dyspnea, bloat, and paraparesis are common clinical features in cattle up to 24 mo of age. 2,23,29 In the thymic form (seen in animals 6–24 mo old), the cervical and/or intrathoracic thymus is usually affected, and clinical signs depend on the location and size of the tumor.…”

“…2,21,27,29 Cervical swelling, dyspnea, bloat, jugular distention, tachycardia, forequarters edema, and fever are typical in the thymic form. 2,21,27,29 In the cutaneous form (seen in animals up to 30 mo old), cutaneous plaques of 1–5 cm diameter can be found on the neck, back, rump, and thigh, and regional lymph nodes are also enlarged. 2,29 In cases of EBL, central or peripheral lymph node enlargement is commonly observed.…”

“…2,29 Although the calf or juvenile form and EBL mainly involve B-cells, thymic and cutaneous forms mainly involve T-cells. 29…”

“…SBL is typically classified into 3 forms: calf or juvenile form, thymic form, and cutaneous form. 2,10,29 SBL usually affects cattle <3 y old; EBL usually affects those >3 y old. 2,29 In the calf or juvenile form, sudden onset of lymphoid hyperplasia, weight loss, fever, tachycardia, dyspnea, bloat, and paraparesis are common clinical features in cattle up to 24 mo of age.…”