Miscellaneous drugs, materials, medical devices, and techniques

Choulis, N.H.

doi:10.1016/b978-0-444-53741-6.00049-0

Cited by 13 publications

(3 citation statements)

References 89 publications

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“…The most abundant source of MUFAs in the human diet (~90% of total MUFAs) is C18:1 (38) which is an omega-9 fatty acid considered partially essential since endogenous synthesis can compensate for dietary deficiencies in organs such as the brain while leading to a reduction in concentration in other organs (39). C18:1 is also used in the pharmaceutical industry as an emulsifying or solubilizing agent (40). C18:1 content in BSF larvae biomass was 21% of the total fatty acid profile based on our chemical analysis.…”

Section: Introductionmentioning

confidence: 99%

Metabolic modeling ofHermetia illucenslarvae resource allocation for high-value fatty acid production

Grausa

Siddiqui

Lameyer

et al. 2022

Preprint

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All plant and animal kingdom organisms use highly connected biochemical networks to facilitate sustaining, proliferation and growth functions. While biochemical network details are well known, the understanding of intense regulation principles is still limited. We chose to investigate Hermetia illucens fly at the larval stage as it is crucial for successful resource accumulation and allocation for the consequential organism's developmental stages. We combined the iterative wet lab experiments and innovative metabolic modeling design approaches, to simulate and explain the H. illucens larval stage resource allocation processes and biotechnology potential. We performed time-based growth and high-value chemical compound accumulation wet lab chemical analysis experiments in larvae and Gainesville diet composition. To predict diet-based alterations on fatty acid allocation potential, we built and validated the first H. illucens medium-size stoichiometric metabolic model. Using optimization methods like Flux balance and Flux variability analysis on the novel insect metabolic model, it predicted that doubled essential amino acid consumption increased the growth rate by 32%, but pure glucose consumption had no positive impact on growth. In the case of doubled pure valine consumption, the model predicted a 2% higher growth rate. In this study, we describe a new framework to research the impact of dietary alterations on the metabolism of multi-cellular organisms at different developmental stages for improved, sustainable and directed high-value chemicals.

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Section: Introductionmentioning

confidence: 99%

Metabolic modeling ofHermetia illucenslarvae resource allocation for high-value fatty acid production

Grausa

Siddiqui

Lameyer

et al. 2022

Preprint

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“…Oleic acid is a fatty acid molecule found in many animal and vegetable fats. In the pharmaceuticals sector, oleic acid is used as an emulsifying or solubilizing agent in aerosol products [1]. It is used as a soap base and in the production of food-grade additives, ointments, cosmetics and many more.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Molecularly Imprinted Polymer with Oleic Acid as a Template

Azhar

Muyang

Maniam

et al. 2022

KEM

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Molecularly Imprinted Polymer-Oleic Acid (MIPOA) and Molecularly Imprinted Polymer-Palmitic Acid (MIPPA) were synthesized using oleic acid and palmitic acid as the templates; acetonitrile as the porogenic solvent; and allylthiourea as the monomer; and EDGMA as a cross-linker via bulk polymerization. The non-imprinted polymers (NIP) as a control were prepared with the same procedure, but with the absence of template molecule. The synthesized MIPs and NIP were characterized using Fourier Transform Infrared Spectroscopy (FTIR) and the results showed the narrowing of –OH peak which shows that crosslinking has occurred. Field Emission Scanning Electron Microscope-Energy Dispersive X-Ray (FESEM-EDX) was used to analyze the composition of in both MIPs and NIP. The results yielded a composition of C, O, and S. This analysis corresponds to the composition of oleic acid and sulfuric acid as both templates contain -COOH group. These results suggested that the molecularly imprinted polymers can be employed as a potential adsorbent for the removal of oleic acid and palmitic acid from palm fatty acid distillate (PFAD) waste.

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“…Table S5. Physical characteristics of the selected TRAVO-loaded LCNs after sterilization by gamma irradiation at different doses (References [ 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ] are cited in the Supplementary Materials).…”

mentioning

confidence: 99%

Travoprost Liquid Nanocrystals: An Innovative Armamentarium for Effective Glaucoma Therapy

et al. 2023

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To date, the ophthalmic application of liquid crystalline nanostructures (LCNs) has not been thoroughly reconnoitered, yet they have been extensively used. LCNs are primarily made up of glyceryl monooleate (GMO) or phytantriol as a lipid, a stabilizing agent, and a penetration enhancer (PE). For optimization, the D-optimal design was exploited. A characterization using TEM and XRPD was conducted. Optimized LCNs were loaded with the anti-glaucoma drug Travoprost (TRAVO). Ex vivo permeation across the cornea, in vivo pharmacokinetics, and pharmacodynamic studies were performed along with ocular tolerability examinations. Optimized LCNs are constituted of GMO, Tween® 80 as a stabilizer, and either oleic acid or Captex® 8000 as PE at 25 mg each. TRAVO-LNCs, F-1-L and F-3-L, showed particle sizes of 216.20 ± 6.12 and 129.40 ± 11.73 nm, with EE% of 85.30 ± 4.29 and 82.54 ± 7.65%, respectively, revealing the highest drug permeation parameters. The bioavailability of both attained 106.1% and 322.82%, respectively, relative to the market product TRAVATAN®. They exhibited respective intraocular pressure reductions lasting for 48 and 72 h, compared to 36 h for TRAVATAN®. All LCNs exhibited no evidence of ocular injury in comparison to the control eye. The findings revealed the competence of TRAVO-tailored LCNs in glaucoma treatment and suggested the potential application of a novel platform in ocular delivery.

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Miscellaneous drugs, materials, medical devices, and techniques

Cited by 13 publications

References 89 publications

Metabolic modeling ofHermetia illucenslarvae resource allocation for high-value fatty acid production

Metabolic modeling ofHermetia illucenslarvae resource allocation for high-value fatty acid production

Synthesis and Characterization of Molecularly Imprinted Polymer with Oleic Acid as a Template

Travoprost Liquid Nanocrystals: An Innovative Armamentarium for Effective Glaucoma Therapy

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