Miscarriage of pregnancy: modern approaches to diagnostics, prevention, and treatment

Zhivetskaya–Denisova, A.A.; Vorobyova, І.I.; Tkachenko, V. B.; Rudakova, N.V.

doi:10.15574/pp.2017.70.91

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Д ослідження проблеми невиношування вагітності (НВ) та розуміння основних ланок його патогенезу є одним з пріоритетних напрямків сучасного акушерства. Частота цієї патології сягає майже 30 % і, не маючи тенденції до зниження, безпосередньо впливає на демографічну ситуацію в країні [1,3]. Актуальність проблеми зумовлена не тільки медичними, але й соціальними аспектами, оскільки НВ призводить до зниження народжуваності, високої перинатальної смертності недоношених новонароджених, інвалідизації дітей [8].…”

Section: н а д о п о м о г у л і к а р ю -п р а к т и к уunclassified

Non-invasive prognostic markers of the risk of preterm rupture of the membranes in premature pregnancy

Lyubomyrska¹,

Syusyuka

Krut

et al. 2022

RHW

View full text Add to dashboard Cite

The objective: to study the prognostic significance of non-invasive markers of endogenous intoxication for determining the risk of premature rupture of membranes (PROM) at the gestation period of 26–34 weeks.Materials and methods. During the study the patients were divided into two groups: the 1st (main) group – 80 women with PROM at 26–34 weeks of pregnancy, and the 2nd (control) group – 50 women with a physiological course of pregnancy and term delivery without complications. The mean age of the examined women was 29.60±6.30 years. To determine the diagnostic value of the level of hematological indicators (concentration of leukocytes (WBC), granulocytes (GRAN), lymphocytes (LYM) in peripheral blood) and indices of endogenous intoxication (EI) as predictors of PROM and the initiation of preterm labor at a gestation period of 26–34 weeks, ROC-analysis was performed and the average quality of these prognostic factors was established (p<0.001).Results. The optimal cut-off point (cut-off value) for predicting PROM in preterm pregnancy according to the criterion of the maximum balance between sensitivity and specificity corresponded to WBC was more than 12.39/l, LYM – less than 19 %, GRAN – more than 76 %, NLR – more than 3.87, Kalf-Kalif’s leukocyte intoxication index (LII) is more than 3.42, Ostrovsky’s LII – more than 2.76. It was established that the area under the curve (AUROC) was 0.786 for WBC, 0.863 for LYM, 0.847 for GRAN, 0.866 for NLR, 0.753 for LII Ostrovsky, which testifies to the significant prognostic value of the studied predictors. Conclusions. The main non-invasive markers of the degree of activity of the inflammatory process and the severity of endogenous intoxication in premature birth with PRPO in pregnant women are: the total number of leukocytes, the level of granulocytes and lymphocytes, Kalf-Kalif LII and the neutrophil-lymphocyte ratio. In order to detect infectious markers of intra-amniotic infection and the further development of PROM and premature birth, it is recommended to calculate the level of endogenous intoxication in the second half of pregnancy using general blood analysis data on a hemolytic analyzer (WBC, GRAN, LYM, NLR).

show abstract

Section: н а д о п о м о г у л і к а р ю -п р а к т и к уunclassified

Non-invasive prognostic markers of the risk of preterm rupture of the membranes in premature pregnancy

Lyubomyrska¹,

Syusyuka

Krut

et al. 2022

RHW

View full text Add to dashboard Cite

show abstract

“…Застосування вітамінно-мінеральних комплексів рекомендується як у випадках фізіологічного перебігу вагітності, так і на прегравідарному етапі для вагітних з обтяженим акушерським анамнезом і ускладненим перебігом гестаційного процесу. Необхідність призначення як окремих вітамінів, так і мультивітамінних препаратів розглядається через призму подолання оксидантного стресу при ускладненнях вагітності [3,6].…”

Section: а к у ш е р с т в оunclassified

Obstetric and perinatal aspects of retrochorial hematomas

Vdovychenko

Zhuk

Salnikov

2021

RHW

View full text Add to dashboard Cite

The problem of pregnancy loss has medico-social, scientific and practical significance. Almost 85% of pregnancy loss occur in the I trimester of gestation (up to 13 weeks), and 15% – II and III trimesters. One of the causes of bleeding in the I trimester of gestation is retrochorial hematoma (RCH) – the accumulation of blood in the retrochorial space due to partial detachment of the chorionic plate from the adjacent of decidua in a genetically normal embryo. The article provides an analysis of scientific publications that highlight the obstetric and perinatal aspects of the characteristics of RCH, the etiological features of their occurrence and important points of the treatment to avoid the development of further complications, the preservation and prolongation of pregnancy. The features of diagnostics and subsequent therapy to provide early support for pregnancy and reduce the incidence of gestational complications are considered. Ultrasound examination of the uterus is of the great prognostic importance in the diagnosis of RCH, which can identify the threatening signs of pregnancy associated with preterm birth, development of fetal growth retardation, placental abruption in the ІІ and ІІІ trimesters, low fetal birth weight. The data of modern researches indicate that the diagnosis of RCH in the presence of a living genetically normal embryo, the appointment of pathogenetic therapy based on gestagenic and antifibrinolytic therapy is the key for the success of treatment of this perinatal pathology, a significantly decreasing the rate of pregnancy losses and an improvement in the quality of gestational process. Today, obstetricians and gynecologists have a deal with the task to find new preclinical signs to predict possible complications of pregnancy and develop effective algorithms for prevention and treatment, which will prolong pregnancy with RCH and achieve positive perinatal outcomes.

show abstract

Miscarriage of pregnancy: modern approaches to diagnostics, prevention, and treatment

Cited by 2 publications

References 0 publications

Non-invasive prognostic markers of the risk of preterm rupture of the membranes in premature pregnancy

Non-invasive prognostic markers of the risk of preterm rupture of the membranes in premature pregnancy

Obstetric and perinatal aspects of retrochorial hematomas

Contact Info

Product

Resources

About