Mirtazapine treatment after conditioning with methamphetamine alters subsequent expression of place preference

Herrold, Amy A.; Shen, Fei; Graham, Martin P.; Harper, Laura; Specio, Sheila E.; Tedford, Clark E.; Napier, T. Celeste

doi:10.1016/j.drugalcdep.2008.08.005

Cited by 38 publications

(38 citation statements)

References 48 publications

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“…Therefore, this demonstrates the importance of the activation of D1-R/MEK/ERK/pElk-1 in the NAc on the development and expression of METH-CPP. In contrast, the METH-CPP testing reduced pERK and pCREB in the NAc after a single pairing session with 2 days withdrawal 182 , suggesting either a compensatory reduction in response to overactivation of ERK signaling during conditioning and withdrawal or other molecular cascades are required for the initial acquisition of METH-CPP. Both assumptions should be further deciphered to identify molecular mechanisms underlying the difference between single and multiple condition session-mediated METH-CPP.…”

Section: Erk Signaling and Drug Addictionmentioning

confidence: 83%

Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects

Sun

Quizon

Zhu

2016

Progress in Molecular Biology and Translational Science

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Addiction to psychostimulants has been considered as a chronic psychiatric disorder, characterized by craving and compulsive drug seeking and use. Over the past two decades, accumulating evidence has demonstrated that repeated drug exposure causes long-lasting neurochemical and cellular changes that results in enduring neuroadaptation in brain circuitry and underlie compulsive drug consumption and relapse. Through intercellular signaling cascades, drugs of abuse induce remodeling in the rewarding circuitry that contributes to the neuroplasticity of learning and memory associated with addiction. Here, we review the role of the extracellular signal-regulated kinase (ERK), a member of the mitogen-activated protein kinase, and its related intracellular signaling pathways in drug-induced neuroadaptive changes that are associated with drug-mediated psychomotor activity, rewarding properties and relapse of drug seeking behaviors. We also discuss the neurobiological and behavioral effects of pharmacological and genetic interferences with ERK-associated molecular cascades in response to abused substances. Understanding the dynamic modulation of ERK signaling in response to drugs may provide novel molecular targets for therapeutic strategies to drug addiction.

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Section: Erk Signaling and Drug Addictionmentioning

confidence: 83%

Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects

Sun

Quizon

Zhu

2016

Progress in Molecular Biology and Translational Science

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“…Environmental cues that had been previously associated with the drug state can be powerful determinants in relapse (Aguilar et al 2009). The conditioned place preference (CPP) paradigm is widely used to study the rewarding and aversive effects of drugs (Tzschentke 2007;Herrold et al 2009). Drug-induced CPP behavior requires memory of learned associations between environmental cues and the compulsive or rewarding properties of drug use (Hsu et al 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Drug-induced CPP behavior requires memory of learned associations between environmental cues and the compulsive or rewarding properties of drug use (Hsu et al 2002). This task exploits the phenomenon that cues such as an environmental context or ''place'' undergo memory consolidation when temporally paired with drug administration and present the salient attributes of the drug so that the individual will prefer to associate with that context even in the absence of a drug (Tzschentke 2007;Herrold et al 2009). The cues in the CPP paradigm model elicit conditioning that may promote the drugseeking behavior or underlie the relapse of drug addition.…”

Section: Introductionmentioning

confidence: 99%

The Activation of NMDA Receptor–ERK Pathway in the Central Amygdala is Required for the Expression of Morphine-Conditioned Place Preference in the Rat

Wang

Dai

et al. 2011

Neurotox Res

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Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in the rat and characterized the role of N-methyl-D: -aspartate (NMDA) receptor and the phosphorylation of extracellular signal-regulated kinase (ERK) in the central nuclei of amygdala (CeA) in the expression of morphine-induced CPP. We have found that morphine repeated pairing treatment causes a significant preference for compartment paired with morphine after 1 day or 7 days post-training, which is associated with increased ERK1/2 phosphorylation (p-ERK1/2, a measure of ERK activity) in the CeA. More than 80% of the positive p-ERK1/2 neurons express NMDA receptor subunit NR1 by double immunofluorescence studies. The infusion of either MEK inhibitor U0126 or NMDA receptor antagonist MK-801 in the CeA not only suppresses the activation of ERK1/2 in the CeA but also abolishes the expression of CPP. These results suggest that the activation of the NMDA receptor-ERK signaling pathway in the CeA is required for the expression of morphine-induced place preference in the rat.

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“…Mirtazapine was administered intraperitoneally (ip) as 5.0mg/ml/kg. This dose was selected based on our extensive prior studies showing that it is sufficient to reduce several forms of methamphetamine- (Graves and Napier, 2011;Herrold et al, 2009;McDaid et al, 2007;Voigt et al, 2011;Voigt and Napier, 2011), and morphine- (Graves et al, 2012a) motivated behaviors in rats without increasing latency to lever press in cue reactivity paradigm or altering coordinated motor function on a rotarod (Graves and Napier, 2011). Ketanserin tartrate (Sigma-Aldrich, St. Louis, MO) was dissolved in sterile H 2 O and administered ip at doses of 1.0, 2.5, or 5.0mg/ml/kg (as the free base).…”

Section: Methodsmentioning

confidence: 99%

“…Mirtazapine is an atypical antidepressant with a complex pharmacological profile that includes antagonism at 5-HT 2A/2C receptors (De Boer, 1995;Wikstrom et al, 2002). Mirtazapine attenuates various behaviors motivated by abused drugs, including methamphetamine (Herrold et al, 2009;Voigt et al, 2011;Graves and Napier, 2011;Voigt and Napier, 2011) and morphine (Graves et al, 2012a) in rats, and reduces cocaine intake in humans (Graves et al, 2012b). We recently revealed that mirtazapine reduces the capacity of the dopamine D2/D3 receptor agonist, pramipexole, to induce risky decision-making by rats performing a probability discounting task (Holtz et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Mirtazapine and ketanserin alter preference for gambling-like schedules of reinforcement in rats

Persons

Tedford

Celeste

2017

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Drug and behavioral addictions have overlapping features, e.g., both manifest preference for larger, albeit costlier, reinforcement options in cost/benefit decision-making tasks. Our prior work revealed that the mixed-function serotonergic compound, mirtazapine, attenuates behaviors by rats motivated by abused drugs. To extend this work to behavioral addictions, here we determined if mirtazapine and/or ketanserin, another mixed-function serotonin-acting compound, can alter decision-making in rats that is independent of drug (or food)-motivated reward. Accordingly, we developed a novel variable-ratio task in rats wherein intracranial self-stimulation was used as the positive reinforcer. Using lever pressing for various levels of brain stimulation, the operant task provided choices between a small brain stimulation current delivered on a fixed-ratio schedule (i.e., a predictable reward) and a large brain stimulation delivered following an unpredictable number of responses (i.e., a variable-ratio schedule). This task allowed for demonstration of individualized preference and detection of shifts in motivational influences during a pharmacological treatment. Once baseline preference was established, we determined that pretreatment with mirtazapine or ketanserin significantly decreased preference for the large reinforcer presented after gambling-like schedules of reinforcement. When the rats were tested the next day without drug, preference for the unpredictable large reinforcer option was restored. These data demonstrate that mirtazapine and ketanserin can reduce preference for larger, costlier reinforcement options, and illustrate the potential for these drugs to alter behavior.

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Mirtazapine treatment after conditioning with methamphetamine alters subsequent expression of place preference

Cited by 38 publications

References 48 publications

Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects

Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects

The Activation of NMDA Receptor–ERK Pathway in the Central Amygdala is Required for the Expression of Morphine-Conditioned Place Preference in the Rat

Mirtazapine and ketanserin alter preference for gambling-like schedules of reinforcement in rats

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