Mirtazapine, in orodispersible form, for patients with preoperative psychological distress: A pilot study

Chou, Wei-Han; Lin, Feng-Sheng; Lin, Chih-Peng; Lin, Wen-Ying; Yie, Jr-Chi; Sun, Wei‐Zen

doi:10.1016/j.aat.2015.12.002

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…Our study con rmed the analgesic effects of aprepitant in A/D group and mirtazapine in M/D group compared to dexamethasone alone which were supported with other studies using aprepitant (25,26) and mirtazapine (35)(36)(37) . In contrast to our study, Moon et al, (27) documented that greater amounts of rescue analgesics were required in the aprepitant group.…”

Section: Discussionsupporting

confidence: 90%

Effects of aprepitant /dexamethasone versus mirtazapine/dexamethasone on postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: a randomized controlled trial

Ashoor¹,

Kassim²,

Hasseb³

et al. 2020

Preprint

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Background Co-administration of different antiemetics proved to decrease postoperative nausea and vomiting (PONV) following laparoscopic sleeve gastrectomy (LSG). The investigators compared the combination of aprepitant and dexamethasone (A/D) with the combination of mirtazapine and dexamethasone (M/D) for prevention of PONV in morbidly obese patients undergoing LSG. Methods Ninety patients scheduled for LSG were assigned to receive a single preoperative dose of dexamethasone 8 mg IVI (D group), and in addition to oral aprepitant 80 mg (A/D group) or oral mirtazapine 30 mg (M/D group) in a randomized, double-blind trial. Assessment of PONV was done 0–2 h (early) and 2–24 hours (late). Patients’ level of sedation, satisfaction and postoperative pain were also assessed. Results A/D and M/D groups were superior to D group for complete response 0–24 h after surgery (79.3% for A/D group, 78.6% for M/D group and 20.7% for D group). D group was inferior to A/D and M/D groups regarding collective PONV and use of rescue antiemetics (P < 0.001) 0–24 h after surgery. The peak nausea scores 2–24 h were significantly lower in both A/D and M/D groups vs. D group (P = 0.005). Patients in the M/D group showed higher sedation scores while those in A/D groups showed lower pain scores and less analgesic requirements. A/D and M/D groups were superior to D group regarding the patient’s satisfaction score. Conclusion A/D and M/D combinations were superior to D alone regarding the proportion of patients exhibiting a complete response in preventing PONV associated with LSG. Trial Registration: Clinical Trials. gov Identifier: NCT04013386/ prospectively registered: 09/07/2019, http://www.Clinical Trial.gov

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Section: Discussionsupporting

confidence: 90%

Effects of aprepitant /dexamethasone versus mirtazapine/dexamethasone on postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: a randomized controlled trial

Ashoor¹,

Kassim²,

Hasseb³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…With the increase of age, the sleep quality of elderly patients decreases year by year, so elderly patients are more likely to have sleep disorders. During the perioperative period, due to the influence of psychological factors, surgical trauma and postoperative pain, sleep disorders are easy to occur 20 . In this study, the effect of propofol‐based TIVA on sleep disorders in elderly patients was observed.…”

Section: Discussionmentioning

confidence: 86%

“…During the perioperative period, due to the influence of psychological factors, surgical trauma and postoperative pain, sleep disorders are easy to occur. 20 In this study, the effect of propofolbased TIVA on sleep disorders in elderly patients was observed.…”

Section: Discussionmentioning

confidence: 93%

Effect of propofol‐based total intravenous anaesthesia on postoperative cognitive function and sleep quality in elderly patients

et al. 2021

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Colorectal surgery is a common surgical operation in clinic, and general anaesthesia is often used during the operation. As the surgery is a traumatic operation, the body will produce a series of stress reactions, leading to postoperative gastrointestinal adverse reactions such as abdominal pain and vomiting, which are not conducive to postoperative rehabilitation. Especially in elderly patients, with the increase of age, there are more basic diseases, coupled with the deterioration of the physiological function of the organs, which reduces the rate of drug metabolism and promotes the body's sensitivity to anaesthetic drugs. Residual drugs will affect the function of the central nervous system, leading to reduced respiratory function, delayed recovery and cognitive dysfunction and other related complications. 1,2 The occurrence of cognitive dysfunction will prolong the hospital stay of elderly

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“…Caregiving status was significantly associated with psychological distress [5]. Psychological distress is also related to limitations in day-to-day activities due to emotional problems [6], maladaptive use of both the Internet and the mobile phone [7], smoking status [8], higher suicidal ideation, even when accounting for resiliency [9], preoperative anxiety, depression, and postoperative pain [10], psychosocial work environment [11], sleep disturbances [12], quality of life [13], and impaired health-related quality of life [14]. The severity of psychological distress is negatively associated with job satisfaction [15].…”

Section: Background To the Studymentioning

confidence: 99%

Mediating Roles of Resilience and Optimism between Work Demand and Psychological Distress among Pre-School Pupils’ Caregivers

Shoaga¹,

Oni²,

Mabekoje³

et al. 2017

IOSR JHSS

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Abstract:Psychological distress has become a serious issue with consequent negative outcomes on individuals and organisations. This study investigated the mediating roles of resilience and optimism between work demand and psychological distress among preschool pupils' caregivers in Ekiti State, Nigeria. A descriptive survey research design was adopted. A sample of 605 caregivers was chosen through stratified random sampling technique. Data were collected using: (i) Demographic Data Form, (ii) Kessler Psychological Distress Scale, (iii) Perceived Work Demand Scale, (iv) Connor-Davison Resilience Scale, and (v) Life Orientation Test Revised. Data were analyzed using Regression Analysis and Pearson Product Moment Correlation Coefficient with result tested for significant at .05 level. Findings revealed, among other things, that there is a significant positive relationship between psychological distress and resilience (r = .263; p <.001), but not between psychological distress and optimism (r = .010; p >.05) and psychological distress and work demand (r = .071; p >.05). There was no significant direct effect of work demand on psychological distress of caregivers, independent of resilience and optimism (coeff = -.043; p >.05). Resilience mediated between work demand and psychological distress of preschool pupils' caregivers. However, neither optimism nor both resilience and optimism did not. The study concluded that resilience and optimism are not significant mediators between work demand and psychological distress of preschool pupils' caregivers. Based on the findings, it was recommended, among others that other factors that could cause a positive relationship between psychological distress and resilience should be identified, isolated, and controlled for further research.

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Mirtazapine, in orodispersible form, for patients with preoperative psychological distress: A pilot study

Abstract: Mirtazapine helps reduce anxiety, depression, and insomnia scores for patients with perioperative psychological distress.

Cited by 5 publications

References 27 publications

Effects of aprepitant /dexamethasone versus mirtazapine/dexamethasone on postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: a randomized controlled trial

Effects of aprepitant /dexamethasone versus mirtazapine/dexamethasone on postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: a randomized controlled trial

Effect of propofol‐based total intravenous anaesthesia on postoperative cognitive function and sleep quality in elderly patients

Mediating Roles of Resilience and Optimism between Work Demand and Psychological Distress among Pre-School Pupils’ Caregivers

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