Mirtazapine attenuates nicotine-seeking behavior in rats

Barbosa-Méndez, Susana; Salazar-Juárez, Alberto

doi:10.1177/0269881118764991

Cited by 12 publications

(4 citation statements)

References 41 publications

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“…It was reported that various antidepressants were effective in treatment of both addiction and chronic itch. For example, mirtazapine attenuates nicotine‐seeking behaviour in rats . In addition, to the previous study it was suggested that various antidepressants may be valuable tools for elucidating the involvement of 5‐HT and noradrenaline in the pruriceptive system…”

Section: Therapeutic Considerationsmentioning

confidence: 99%

Addiction and the itch‐scratch cycle. What do they have in common?

Ishiuji

2019

Experimental Dermatology

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Itch is a multidimensional experience involving various brain regions associated with sensory perception and emotion, as well as an urge to scratch employing the motor system. Scratch temporarily relieves itch sensation in healthy subjects. However, in patients with chronic itch, rather than inhibit, scratch may aggravate itch. Patients with chronic itch, such as those with atopic dermatitis, experience severe itch and a strong desire to scratch. This urge to scratch is the driving force underlying the formation of the itch‐scratch‐cycle, an addictive and vicious cycle in chronic itch patients. This vicious itch‐scratch behaviour and various types of addiction (henceforth, including recreational drug use) were shown to share common sensory mechanisms. Abnormalities have been observed in central neural circuits, including the reward, motivation/drive, control and learning/memory circuits, as well as other brain systems. Reward systems, including the ventral tegmental area (VTA), nucleus accumbens (NAc) and striatum, are important for brain processing of both addiction and itch. In addition to reward, addicted individuals can experience severe disruptions in motor control, cognitive awareness, executive function, learning/memory and even emotional functions. Findings showing that addiction and itch share a common neurobiological foundation could have important mechanistic and therapeutic implications. Here we propose that similar neuroadaptations exist in addiction and chronic itch patients.

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Section: Therapeutic Considerationsmentioning

confidence: 99%

Addiction and the itch‐scratch cycle. What do they have in common?

Ishiuji

2019

Experimental Dermatology

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“…These results are like those reported by our laboratory, where the daily dosage of mirtazapine during withdrawal decreased the induction and expression of cocaine-induced locomotor sensitization in intact female rats (Barbosa-Méndez et al ., 2020). Other studies in male Wistar rats demonstrated that the daily dosage of mirtazapine decreased the induction and expression of locomotor sensitization to methamphetamine, cocaine, and nicotine (Graves et al ., 2012b; Salazar-Juárez et al ., 2016; Barbosa-Méndez et al ., 2017c), decreases the duration of cocaine-induced locomotor effect (Barbosa-Méndez et al ., 2017b), reduced the methamphetamine, cocaine, and nicotine self-administration (Graves and Napier, 2011; Barbosa-Méndez et al ., 2017a; Barbosa-Méndez and Salazar-Juárez 2018), and attenuates the anxiety- and depression-like behaviors (Barbosa-Mendez and Salazar-Juarez, 2019) during cocaine-withdrawal (Barbosa-Méndez et al ., 2020). These results support the efficacy of mirtazapine to attenuate cocaine-induced psychostimulant and reinforcing effects in intact male and female rats.…”

Section: Discussionmentioning

confidence: 99%

“…In male rodents, the daily dosage of mirtazapine during withdrawal decreased the induction and expression of locomotor sensitization to methamphetamine, cocaine, and nicotine (Graves and Napier, 2012a; Salazar-Juárez et al, 2016; Barbosa-Méndez et al ., 2017c; 2018), decreases the duration of cocaine-induced locomotor effect (Barbosa-Méndez et al ., 2017b), reduced the methamphetamine, cocaine, and nicotine self-administration (Graves and Napier, 2011; Barbosa-Méndez et al ., 2017a; Barbosa-Méndez and Salazar-Juárez 2018), and attenuates the anxiety- and depression-like behaviors (Barbosa-Mendez and Salazar-Juarez, 2019) during cocaine-withdrawal. Recently, we reported that mirtazapine decreased the induction and expression of cocaine-induced locomotor sensitization in female rats (Barbosa-Méndez et al ., 2020).…”

Section: Introductionmentioning

confidence: 99%

Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats

Barbosa-Méndez,

Salazar-Juárez

2023

Behavioural Pharmacology

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Epidemiological studies have mentioned that cocaine use disorder (CUD) has increased in the last decade among women; these show endocrine and reproductive disorders and a high propensity to stress and depression disorders. Mirtazapine—a tetracyclic antidepressant—decreases cocaine-induced locomotor activity and locomotor sensitization in male rats. The objective of this study was to evaluate if estradiol alters the efficacy of mirtazapine to decrease cocaine-induced locomotor activity in sham and ovariectomized female rats. Three hundred and twenty adult female Wistar rats were assigned to three experimental protocols. For experiments, 1–3, female rats were daily dosed with 10 mg/kg of cocaine during the 10 days of induction and expression of locomotor sensitization. During drug withdrawal (30 days), cocaine was withdrawn and the groups received daily mirtazapine, estradiol, or saline. In addition, the females underwent sham or ovariectomy surgery. Tamoxifen was administered during the antagonism phase. After each administration, locomotor activity for each animal was recorded for 30 min in activity chambers. The dosage of mirtazapine reduces estradiol-induced enhancement in cocaine-dependent locomotor activity during the expression of locomotor sensitization in sham and ovariectomized female rats. As well as they showed that estradiol co-dosed with mirtazapine enhances the efficacy of mirtazapine to decrease cocaine-induced locomotor activity. Finally, tamoxifen enhanced the estradiol and mirtazapine-induced decrease in the cocaine motor effect in female rats. Mirtazapine may be considered an effective therapeutic option for the treatment of CUD in women, even in those who are on hormonal treatment or antidepressant therapy with estradiol.

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“…The cocaine or food self-administration procedures were performed according to a method described elsewhere. 58 , 59 Briefly, the rats were trained to self-administer cocaine using a 1 mg/kg cocaine unit dose (30 μl/infusion/30 sec), in daily 2-h sessions (FR5 with 2-min TO) for 6 days per week (Complete methods in Supplementary Material).…”

Section: Methodsmentioning

confidence: 99%

COT-TT vaccine attenuates cocaine-seeking and cocaine-conditioned place preference in rats

Barbosa-Méndez,

Matus-Ortega,

Hernandez-Miramontes

et al. 2024

Human Vaccines & Immunotherapeutics

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Vaccination active, promising alternative immunological strategy to treat of CUD. Various models of cocaine vaccines have been evaluated in animals and humans with relative success. In this sense, it is necessary to improve or optimize the cocaine vaccines already evaluated. Our laboratory previously reported the efficacy of the tetanus toxoid-conjugated morphine vaccine (M 6 -TT). The M 6 -TT vaccine can generate high titers of antibodies and reduce heroin-induced behavioral effects in rodents. So, it would be plausible to assume that if we modify the M 6 -TT vaccine by changing the hapten and maintaining the rest of the structural elements of the vaccine, we will maintain the properties of the M 6 -TT vaccine (high antibody titers). The objective of this study was to determine whether the antibodies generated by a tetanus toxoid-conjugated cocaine vaccine (COC-TT) can recognize and capture cocaine and decrease the cocaine-induced reinforcing effects. Male Wistar rats were immunized with the COC-TT. A solid-phase antibody-capture ELISA was used to monitor antibody titer responses after each booster dose in vaccinated animals. The study used cocaine self-administration and place-preference testing to evaluate the cocaine-reinforcing effects. The COC-TT vaccine could generate high levels of anti-cocaine antibodies. The antibodies reduced the cocaine self-administration and cocaine place preference. In addition, they decreased the cocaine-induced Fos protein expression. These findings suggest that the COC-TT vaccine generates a robust immunogenic response capable of reducing the reinforcing effects of cocaine, which supports its possible future use in clinical trials in patients with CUD.

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Mirtazapine attenuates nicotine-seeking behavior in rats

Abstract: These results support the use of mirtazapine in clinical controlled trials as a useful therapy that prolongs and increases rates of preventing relapse into nicotine intake in humans.

Cited by 12 publications

References 41 publications

Addiction and the itch‐scratch cycle. What do they have in common?

Addiction and the itch‐scratch cycle. What do they have in common?

Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats

COT-TT vaccine attenuates cocaine-seeking and cocaine-conditioned place preference in rats

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