Mirtazapine as Treatment for Serotonin Syndrome

Hoes, M.J.A.J.M.; Zeijpveld, J. H.B.

doi:10.1055/s-2007-979550

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion3

Citation Types

Supporting

Mentioning

Contrasting

Unclassified

Year Published

1998

2022

Publication Types

Select...

Article7

Book2

Relationship

Self Cite0

Independent9

Authors

Journals

Cited by 32 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, a serotonin syndrome seems rather improbable in the present case because of the 5-HT 2 and 5-HT 3 -receptor antagonising nature of mirtazapine. There is also a report of treating serotonin syndrome with mirtazapine [31].…”

Section: Discussionmentioning

confidence: 99%

Tissue distribution of mirtazapine and desmethylmirtazapine in a case of mirtazapine poisoning

Wenzel

Aderjan

Mattern

et al. 2006

Forensic Science International

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Tissue distribution of mirtazapine and desmethylmirtazapine in a case of mirtazapine poisoning

Wenzel

Aderjan

Mattern

et al. 2006

Forensic Science International

View full text Add to dashboard Cite

“…7 MTZ is chemically unrelated to these substances and lacks anticholinergic properties. [1][2][3] The selective action of MTZ with 5HT 2 -5HT 3 receptor blockade and the lack of fever or myoclonus suggest that the disturbance observed in our patients cannot be attributed to a serotonin syndrome: MTZ is indeed proposed as a treatment for serotonin syndrome. 1 Furthermore, RBD did not recur when patients were treated with paroxetine or citalopram.…”

mentioning

confidence: 61%

“…[1][2][3] This report of remitting RBD induced by a drug lacking anticholinergic properties and blocking 5HT 2 and 5HT 3 receptors suggests that the enhancement of noradrenergic activity, rather then the anticholinergic or serotonergic activity, is a probable causative factor for RBD. rine release and enhancement of noradrenergic neurotrasmission.…”

mentioning

confidence: 80%

Mirtazapine induces REM sleep behavior disorder (RBD) in parkinsonism

Onofrj

Luciano²,

Thomas³

et al. 2003

Neurology

112

View full text Add to dashboard Cite

Shortly after initiation of mirtazapine (a noradrenergic and serotonergic antidepressant) treatment in four patients with parkinsonism, the authors observed the appearance of REM sleep behavior disorder (RBD). In the two patients with severe motor symptoms, RBD was accompanied by hallucinations and confusion. These disturbances resolved with drug discontinuation, and remained resolved by 12- to 24-month follow-up, suggesting that RBD can be triggered by a drug lacking anticholinergic activity.

show abstract

“…6 Chlorpromazine, 7 methysergide, 8 propranolol, 9 and even mirtazapine, 10 have been suggested as treatment for SS.…”

Section: Discussionmentioning

confidence: 99%