Mirror neuron deficit in schizophrenia: Evidence from repetition suppression

Möhring, Nicole; Shen, Christina; Hahn, Eric; Ta, Thi Minh Tam; Dettling, Michael; Neuhaus, Andres H.

doi:10.1016/j.schres.2015.07.035

Cited by 10 publications

(3 citation statements)

References 45 publications

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“…They are known to fire during goal-oriented motor action, but also in response to observing the same action performed by another individual. Previous studies have indicated dysfunction of the mirror-neuron system in both ASD ( Oberman et al, 2005 ; Enticott et al, 2012 ) and SZ ( Mehta et al, 2013 ; Möhring et al, 2015 ) patients. In addition, the ASD model required more features for accurate classification than were required for SZ subjects.…”

Section: Discussionmentioning

confidence: 99%

Differences in atypical resting-state effective connectivity distinguish autism from schizophrenia

Mastrovito

Hanson

2018

NeuroImage: Clinical

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Autism and schizophrenia share overlapping genetic etiology, common changes in brain structure and common cognitive deficits. A number of studies using resting state fMRI have shown that machine learning algorithms can distinguish between healthy controls and individuals diagnosed with either autism spectrum disorder or schizophrenia. However, it has not yet been determined whether machine learning algorithms can be used to distinguish between the two disorders. Using a linear support vector machine, we identify features that are most diagnostic for each disorder and successfully use them to classify an independent cohort of subjects. We find both common and divergent connectivity differences largely in the default mode network as well as in salience, and motor networks. Using divergent connectivity differences, we are able to distinguish autistic subjects from those with schizophrenia. Understanding the common and divergent connectivity changes associated with these disorders may provide a framework for understanding their shared cognitive deficits.

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Section: Discussionmentioning

confidence: 99%

Differences in atypical resting-state effective connectivity distinguish autism from schizophrenia

Mastrovito

Hanson

2018

NeuroImage: Clinical

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“…Mitra et al (89) reported a negative correlation between the mu wave suppression and the thought disturbance cluster on PANSS, proposing that according to the theory that dopamine levels in the brain and the performance of the brain circuits have an "inverted-U" shaped relationship, an increase in brain dopamine levels during schizophrenia possibly disrupts the MNS circuit, leading to psychopathology manifestations. Other studies did not find a significant correlation between positive PANSS scores and MNA (74,78,80,84,86,88,90,96,99,102). These contradictory results could be due to differences in experimental conditions, stage of disease, or the measures used to assess symptoms.…”

Section: Contradictory Results; Some Possible Explanationsmentioning

confidence: 75%

The mirror mechanism in schizophrenia: A systematic review and qualitative meta-analysis

et al. 2022

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BackgroundMirror neuron system (MNS) consists of visuomotor neurons that are responsible for the mirror neuron activity (MNA), meaning that each time an individual observes another individual performing an action, these neurons encode that action, and are activated in the observer's cortical motor system. Previous studies report its malfunction in autism, opening doors to investigate the underlying pathophysiology of the disorder in a more elaborate way and coming up with new rehabilitation methods. The study of MNA function in schizophrenia patients has not been as frequent and conclusive as in autism. In this research, we aimed to evaluate the functional integrity of MNA and the microstructural integrity of MNS in schizophrenia patients.MethodsWe included case-control studies that have evaluated MNA in schizophrenia patients compared to healthy controls using a variety of objective assessment tools. In August 2022, we searched Embase, PubMed, and Web of Science for eligible studies. We used an adapted version of the NIH Quality Assessment of Case-Control Studies tool to assess the quality of the included studies. Evidence was analyzed using vote counting methods of the direction of the effect and was tested statistically using the Sign test. Certainty of evidence was assessed using CERQual.ResultsWe included 32 studies for the analysis. Statistical tests revealed decreased MNA (p = 0.002) in schizophrenia patients. The certainty of the evidence was judged to be moderate. Investigations of heterogeneity revealed a possible relationship between the age and the positive symptoms of participants in the included studies and the direction of the observed effect.DiscussionThis finding contributes to gaining a better understanding of the underlying pathophysiology of the disorder by revealing its possible relation to some of the symptoms in schizophrenia patients, while also highlighting a new commonality with autism.Systematic review registrationPROSPERO identifier: CRD42021236453.

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“…The underlying neural correlation between visual motor processing and emotion recognition in schizophrenia remains obscure, and there were few possible speculative explanations. First, visual motor processing and learning may modulate emotional processing through the mirror neuron system 38,[46][47][48][49] , although some unsupportive arguments exist 50 . Second, evidence supports the association between visual motor processing and emotion recognition may be related to the overlapping modulatory function of the dopaminergic system and subthalamic nucleus, with evidence showing diminished accuracy of emotion recognition in Parkinson's disease patients with movement disturbances [51][52][53][54] .…”

Section: Discussionmentioning

confidence: 99%

Association of visual motor processing and social cognition in schizophrenia

Huang

et al. 2021

npj Schizophr

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Patients with schizophrenia have difficulties in social cognitive domains including emotion recognition and mentalization, and in sensorimotor processing and learning. The relationship between social cognitive deficits and sensorimotor function in patients with schizophrenia remains largely unexplored. With the hypothesis that impaired visual motor processing may decelerate information processing and subsequently affects various domains of social cognition, we examined the association of nonverbal emotion recognition, mentalization, and visual motor processing in schizophrenia. The study examined mentalization using the verbal subset of the Chinese version of Theory of Mind (CToM) Task, an equivalent task of the Faux Pas Test; emotion recognition using the Diagnostic Analysis of Nonverbal Accuracy 2-Taiwan version (DANVA-2-TW), and visual motor processing using a joystick tracking task controlled for basic motor function in 34 individuals with chronic schizophrenia in the community and 42 healthy controls. Patients with schizophrenia had significantly worse performance than healthy controls in social cognition, including facial, prosodic emotion recognition, and mentalization. Visual motor processing was also significantly worse in patients with schizophrenia. Only in patients with schizophrenia, both emotion recognition (mainly in prosodic modality, happy, and sad emotions) and mentalization were positively associated with their learning capacity of visual motor processing. These findings suggest a prospective role of sensorimotor function in their social cognitive deficits. Despite that the underlying neural mechanism needs further research, our findings may provide a new direction for restoration of social cognitive function in schizophrenia by enhancing visual motor processing ability.

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Mirror neuron deficit in schizophrenia: Evidence from repetition suppression

Cited by 10 publications

References 45 publications

Differences in atypical resting-state effective connectivity distinguish autism from schizophrenia

Differences in atypical resting-state effective connectivity distinguish autism from schizophrenia

The mirror mechanism in schizophrenia: A systematic review and qualitative meta-analysis

Association of visual motor processing and social cognition in schizophrenia

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