Mirror-Image DNA Nanobox for Enhancing Environment Resistance of Nucleic Acid Probes
Shiquan Li,
Yihao Liu,
Minze He
et al.
Abstract:Degradation and interference of the nucleic acid probes
in complex
biological environments like cytoplasm or body fluid can cause obvious
false-positive signals and inefficient bioregulation in biosensing
and biomedicine. To solve this problem, here, we proposed a universal
strategy, termed L-DNA assembly mirror-image box-based environment
resistance (L-AMBER), to protect nucleic acid probes from degradation
and maintain their responsive activity in complex biological environments.
Strand displacement reaction… Show more
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