Mirodenafil for the Treatment of Erectile Dysfunction: A Systematic Review of the Literature

Abstract

Phosphodiesterase type 5 (PDE5) inhibitors are the most commonly used treatment for erectile dysfunction (ED). Since the launch of sildenafil, several drugs-including mirodenafil, sildenafil citrate (sildenafil), tadalafil, vardenafil HCL (vardenafil), udenafil, and avanafil-have become available. Mirodenafil is a newly developed pyrrolopyrimidinone compound, which is a potent, reversible, and selective oral PDE5 inhibitor. Mirodenafil was launched in Korea in 2007, and an orally disintegrating film of mirodenafil was developed in 2011 for benefitting patients having difficulty in swallowing tablets. This study aimed to review the pharmacokinetic characteristic profile of mirodenafil and report evidence on its efficacy in the case of ED. In addition, we reviewed randomized controlled studies of mirodenafil's daily administration and efficacy for lower urinary tract symptoms.

The Efficacy of Mirodenafil for Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Middle-Aged Males

“…Mirodenafil is a newly developed pyrrolopyrimidinone compound and a potent selective oral PDE-5 inhibitor [ 14 , 15 ]. Mirodenafil was launched in Korea in 2007, and an orally disintegrating mirodenafil film was developed in 2011 for patients who have difficulty swallowing tablets [ 16 ].…”

Administration of sildenafil citrate not able to reduced hs-CRP on erectile dysfunction patient at Doctor Soetomo Hospital, Surabaya, Indonesia

“…While Tadalafil achieved maximum concentration after 2 hours with a longer half-life, about 17.5 hours and the maximum concentration in blood was 378 ng/ dl. 10 Animal studies indicate daily sildenafil citrate administration for the treatment of endothelial dysfunction and oxidative stress associated with insulin resistance. Other studies have been conducted in humans with good efficacy and safety efficacy from long-term sildenafil citrate during night hours to improve spontaneous erection in men.…”

Diabetes Mellitus and Sexual Dysfunction; A Systematic Review of the Literature with Current Treatment Approaches

“…Mirodenafil is a new option for the treatment of erectile dysfunction in diabetes mellitus patients with sexual dysfunciton. İt is at least as effective as other PDE5 inhibitors [47]. İn addition to treatment, udenafil and mirodenafil may be another option in daily dosing treatment for ED [47,48].…”

“…İt is at least as effective as other PDE5 inhibitors [47]. İn addition to treatment, udenafil and mirodenafil may be another option in daily dosing treatment for ED [47,48]. CHD is not an absolute contraindication for PDE5 inhibitors therapy, but particular caution has to be paid in cases of unstable and severe angina pectoris, recent myocardial infarction, certain arrhythmias, poorly controlled hypertension, and concomitant use of nitrates or nitrate donors: before starting therapy with PDE5 inhibitors, diabetic patients should undergo an overall cardiovascular examination [49].…”