MiRNome of epileptic children suggests the involvement of antioxidant pathways in the neuroprotective role of ketogenic diet

Olaso‐González, Gloria; Serna, Eva; Herrero, Jana Ruiz; Martínez, Cecilia; Pedron, Caio César; Viña, José

doi:10.1016/j.freeradbiomed.2018.04.267

Cited by 3 publications

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“…Interestingly, each of these miRNAs were also altered in epilepsy (Jimenez-Mateos et al, 2011;Peng et al, 2013;Pichardo-Casas et al, 2012). A recent study showed global changes in miRNA expression in pediatric epilepsy patients after KD therapy (Olaso-González et al, 2018). However, many of these miRNAs were involved in antioxidant pathways, suggesting that KD-induced changes in miRNA expression might be involved in the prevention of oxidative stress and therefore be neuroprotective (Cannataro et al, 2019;Olaso-González et al, 2018).…”

Section: Non-coding Rnasmentioning

confidence: 99%

“…A recent study showed global changes in miRNA expression in pediatric epilepsy patients after KD therapy (Olaso-González et al, 2018). However, many of these miRNAs were involved in antioxidant pathways, suggesting that KD-induced changes in miRNA expression might be involved in the prevention of oxidative stress and therefore be neuroprotective (Cannataro et al, 2019;Olaso-González et al, 2018). The array of miRNA changes induced by KD therapy, particularly those involved in epigenetic modifications, need to be further examined.…”

Section: Non-coding Rnasmentioning

confidence: 99%

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Ketogenic diet, neuroprotection, and antiepileptogenesis

Murugan

Boison

2020

Epilepsy Research

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Section: Non-coding Rnasmentioning

confidence: 99%

Section: Non-coding Rnasmentioning

confidence: 99%

Ketogenic diet, neuroprotection, and antiepileptogenesis

Murugan

Boison

2020

Epilepsy Research

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Ketogenic Diet and Epigenetic Mechanisms of Epileptogenesis

Murugan¹,

Tescarollo²,

Boison³

2022

Ketogenic Diet and Metabolic Therapies

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Approximately 60% of all epilepsy cases occur as a consequence of acute insults to the brain, such as traumatic brain injury, cerebrovascular insult, or infections. After an insult, the brain enters a period during which progressive neurobiologic alterations convert a non-epileptic brain into a brain capable of generating spontaneous and recurrent seizures, which are defined as epilepsy. The series of events is known as epileptogenesis. Epigenetic (DNA methylation) changes may affect several genes thought to represent risk factors for epilepsy; epigenetic changes are potentially reversible and may constitute a novel target for therapeutic intervention. DNA hypermethylation related to adenosine deficiency results in a vicious cycle associated with the onset of epileptogenesis and leading to chronic pharmacoresistant epilepsy. DNA hypermethylation is restored by the ketogenic diet (KD) via adenosine augmentation, a shift in the S-adenosylhomocysteine and S-adenosylmethionine homeostasis, and aiding DNA methylation by DNA methyltransferases. The KD-induced increase in ketone bodies inhibits histone deacetylases and prevents histone deacetylation. A clearer understanding of how KD therapy affects adenosine metabolism and its epigenetic sequelae may guide the development of therapies designed to directly restore adenosine homeostasis.

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Ketogenic Diet: A Promising Neuroprotective Composition for Managing Alzheimer’s Diseases and its Pathological Mechanisms

Sridharan

Lee

2022

CMM

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: Ketogenic diet and ketone bodies gained significant attention in recent years due to their ability to influence the specific energy metabolism and restoration of mitochondrial homeostasis that can help in hindering the progression of many metabolic diseases including diabetes and neurodegenerative diseases. Ketogenic diet consists of high fat and low carbohydrate contents which makes the body glucose deprived and rely on alternative sources (ketone bodies) for energy. It has been initially designed and supplemented for the treatment of epilepsy and later its influence on many energy-deriving biochemical pathways made it a highly sorted food supplement for many metabolic diseases and even by healthy individuals for body building and calorie restriction. Among the reported therapeutic action over a range of diseases, neurodegenerative disorders especially Alzheimer’s disease gained the attention of many researchers and clinicians because of its potency and its easier supplementation as a food additive. Complex pathology and multiple influencing factors of Alzheimer’s disease make exploration of its therapeutic strategies a demanding task. It was a common phenomenon that energy deprivation in neurological disorders including Alzheimer’s disease, to progress rapidly. The ability of ketone bodies to stabilize the mitochondrial energy metabolism makes it a suitable intervening agent. In this review, we will discuss various research progress made with regards to ketone bodies/ketogenic diet for management of Alzheimer’s disease and elaborate in detail about the mechanisms that are influenced during their therapeutic action.

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MiRNome of epileptic children suggests the involvement of antioxidant pathways in the neuroprotective role of ketogenic diet

Cited by 3 publications

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Ketogenic diet, neuroprotection, and antiepileptogenesis

Ketogenic diet, neuroprotection, and antiepileptogenesis

Ketogenic Diet and Epigenetic Mechanisms of Epileptogenesis

Ketogenic Diet: A Promising Neuroprotective Composition for Managing Alzheimer’s Diseases and its Pathological Mechanisms

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