MiRNAs in endometrioid endometrial cancer metastatic loci derived from positive lymph nodes

Wilczyński, Miłosz; Senderowska, Daria; Krawczyk, Tomasz; Szymańska, Bożena; Malinowski, Andrzej

doi:10.1111/aogs.13833

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Over the last 5 years, up to 754 miRNAs [17] have been identified as potential biomarkers in EC, some of which are correlated with lymph node involvement, advanced FIGO stage, metastatic status, or histologic type [17,40,103,118,161,162]. Increasing our knowledge of the miRNA expression status or the methylation state of key miRNA loci may help to better stratify patients.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review

Favier

Rocher

Larsen

et al. 2021

Cancers

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The objective of this systematic review is to summarize our current knowledge on the influence of miRNAs in the epigenetic deregulation of tumor-related genes in endometrial cancer (EC). We conducted a literature search on the role of miRNAs in the epigenetic regulation of EC applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following terms were used: microRNA, miRNA, miR, endometrial cancer, endometrium, epigenetic, epimutation, hypermethylation, lynch, deacetylase, DICER, novel biomarker, histone, chromatin. The miRNAs were classified and are presented according to their function (tumor suppressor or onco-miRNA), their targets (when known), their expression levels in EC tissue vs the normal surrounding tissue, and the degree of DNA methylation in miRNA loci and CpG sites. Data were collected from 201 articles, including 190 original articles, published between November 1, 2008 and September 30, 2020 identifying 313 different miRNAs implicated in epigenetic regulation of EC. Overall, we identified a total of 148 miRNAs with decreased expression in EC, 140 miRNAs with increased expression in EC, and 22 miRNAs with discordant expression levels. The literature implicated different epigenetic phenomena including altered miRNA expression levels (miR-182, -230), changes in the methylation of miRNA loci (miR-34b, -129-2, -130a/b, -152, -200b, -625) and increased/decreased methylation of target genes (miR-30d,-191). This work provides an overview of all miRNAs reported to be involved in epigenetic regulation in EC including DNA methylation and RNA-associated silencing. These findings may contribute to novel strategies in diagnosis, risk assessment, and treatments aimed at miRNAs, their target genes or DNA methylation.

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Section: Discussionmentioning

confidence: 99%

MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review

Favier

Rocher

Larsen

et al. 2021

Cancers

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“…Overexpression of miR-501 can increase the activation of the AKT/mTOR pathway, leading to higher pelvic lymph node metastasis and reduced overall survival (106). Profiling the miRNA expression in EEC metastatic loci from lymph nodes could aid in identifying novel diagnostic markers and therapeutic targets (202). miR-204-5p is a tumor-suppressor miRNA associated with lymph node metastasis in EC, highlighting the importance of the lymph node status in determining adjuvant treatment (168).…”

Section: Ec and Tumor-causing Mirnamentioning

confidence: 99%

The interplay of sex steroid hormones and microRNAs in endometrial cancer: current understanding and future directions

Thakur

Thakur²

2023

Front. Endocrinol.

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IntroductionEndometrial cancer is a hormone-dependent malignancy, and sex steroid hormones play a crucial role in its pathogenesis. Recent studies have demonstrated that microRNAs (miRNAs) can regulate the expression of sex steroid hormone receptors and modulate hormone signaling pathways. Our aim is to provide an overview of the current understanding of the role of miRNAs in endometrial cancer regulated by sex steroid hormone pathways.MethodsA thorough literature search was carried out in the PubMed database. The articles published from 2018 to the present were included. Keywords related to miRNAs, endometrial cancer, and sex steroid hormones were used in the search.ResultsDysregulation of miRNAs has been linked to abnormal sex steroid hormone signaling and the development of endometrial cancer. Various miRNAs have been identified as modulators of estrogen and progesterone receptor expression, and the miRNA expression profile has been shown to be a predictor of response to hormone therapy. Additionally, specific miRNAs have been implicated in the regulation of genes involved in hormone-related signaling pathways, such as the PI3K/Akt/mTOR and MAPK/ERK pathways.ConclusionThe regulation of sex steroid hormones by miRNAs is a promising area of research in endometrial cancer. Future studies should focus on elucidating the functional roles of specific miRNAs in sex steroid hormone signaling and identifying novel miRNA targets for hormone therapy in endometrial cancer management.

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“…[ 23 ] Most recent studies deal with FFPE tissue, [ 24 ] DNA methylation, [ 25 ] and miRNA analysis Wilczynski. [ 26 ]…”

Section: Technical Approaches For Laser Based Microdissectionmentioning

confidence: 99%

Microdissection—An Essential Prerequisite for Spatial Cancer Omics

Eggeling

Hoffmann

2020

Proteomics

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The problem with cancer tissue is that its intratumoral heterogeneity and its complexity is extremely high as cells possess, depending on their location and function, different mutations, different mRNA expression and the highest intricacy in the protein pattern. Prior to genomic and proteomic analyses, it is therefore indispensable to identify the exact part of the tissue or even the exact cell. Laser‐based microdissection is a tried and tested technique able to produce pure and well‐defined cell material for further analysis with proteomic and genomic techniques. It sheds light on the heterogeneity of cancer or other complex diseases and enables the identification of biomarkers. This review aims to raise awareness for the reconsideration of laser‐based microdissection and seeks to present current state‐of‐the‐art combinations with omic techniques.

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MiRNAs in endometrioid endometrial cancer metastatic loci derived from positive lymph nodes

Cited by 4 publications

References 21 publications

MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review

MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review

The interplay of sex steroid hormones and microRNAs in endometrial cancer: current understanding and future directions

Microdissection—An Essential Prerequisite for Spatial Cancer Omics

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