miRNAs Expressions and Interaction with Biological Systems in Patients with Alzheimer`s Disease. Using miRNAs as a Diagnosis and Prognosis Biomarker

Negoiță, Silvius; Săndesc, Dorel; Rogobete, Alexandru Florin; Duţu, Mădălina; Bedreag, Ovidiu Horea; Păpurică, Marius; Ercisli, Muhammed F; Popovici, Sonia Elena; Dumache, Raluca; Sandesc, Mihai; Dinu, Anca; Sas, Adriana; Șerban, Denis Mihai; Corneci, Dan

doi:10.7754/clin.lab.2017.170327

Cited by 11 publications

(13 citation statements)

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“…[43][44][45][46] The transporting protein, Exportin 5, will then act on the pre-miRNAs, which will transfer the epigenetic complex from the nucleus to the cell cytoplasm. [47][48][49] Once the signal that the complex has reached the cytoplasm is received, RNA polymerase III (Dicer) and trans-activator RNA binding protein (TRBP) attack it and lead to the formation of mature miRNAs. 5,50 This molecular species is then introduced in Furthermore, regarding the action mechanisms, researchers came to the conclusion that miRNAs are involved in inflammation, in the redox response, nutrient sensing, and silent mating-type information regulation 2 homolog (SIRT1)-regulated events.…”

Section: The Most Common Molecular Mechanisms Involved In Cvdsmentioning

confidence: 99%

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Buzaș

Rogobete

Popovici

et al. 2018

Journal of Cardiovascular Emergencies

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Worldwide, cardiovascular diseases (CVDs) represent one of the main causes of morbidity and mortality, and acute coronary syndromes are responsible for a large number of sudden cardiac deaths. One of the main challenges that still exist in this area is represented by the early detection and targeted monitoring of the pathophysiology involved in CVDs. During the last couple of years, researchers have highlighted the importance of molecular and epigenetic mechanisms involved in the initiation and augmentation of CVDs, culminating in their most severe form represented by acute myocardial infarction. One of the most studied molecular factors involved in this type of pathology is represented by nuclear transcription factor kappa B (NF-κB), as well as the involvement of microRNAs (miRNAs). It has been suggested that miRNAs can also be involved in the complex process of atheromatous plaque vulnerabilization that leads to an acute cardiac event. In this review paper, we describe the most important molecular mechanisms involved in the pathogenesis of CVDs and atheromatous plaque progression and vulnerabilization, which include molecular mechanisms dependent on NF-κB. For this paper, we used international databases (PubMed and Scopus). The keywords used for the search were “miRNAs biomarkers”, “miRNAs in cardiovascular disease”, “NF-κB in cardiovascular disease”, “molecular mechanism in cardiovascular disease”, and “myocardial NF-κB mechanisms”. Numerous molecular reactions that have NF-κB as a trigger are involved in the pathogenesis of CVDs. Moreover, miRNAs play an important role in initiating and aggravating certain segments of CVDs. Therefore, miRNAs can be used as biomarkers for early evaluation of CVDs. Furthermore, in the future, miRNAs could be used as a targeted molecular therapy in order to block certain mechanisms responsible for inducing CVDs and leading to acute cardiovascular events.

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Section: The Most Common Molecular Mechanisms Involved In Cvdsmentioning

confidence: 99%

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Buzaș

Rogobete

Popovici

et al. 2018

Journal of Cardiovascular Emergencies

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“…10,11 Furthermore, miRNAs exert these function in various human cancers and serve as a kind of biomarkers. 12 MiR-186-5p, an endogenous miRNA, has been reported to exert function as a tumor suppressor in osteosarcoma and inhibits cell proliferation as well as metastasis through regulation of zinc nger E-box binding (ZEB) in human colorectal cancer. 13 Besides, Lin et al reported that microRNA-186-5p (miR-186-5p) induced chronic myeloid leukemia (CML) cell apoptosis and reduced cell survival.…”

Section: Introductionmentioning

confidence: 99%

Retracted Article: Long non-coding RNA KCNQ1OT1 regulates cell proliferation, apoptosis and chemo-sensitivity through modulating the miR-186-5p/NCAM1 axis in acute myeloid leukemia cells

et al. 2019

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“…Accumulating evidence shows that miRNAs are involved in the regulation of human cancers and can be used as the diagnosis and therapeutic targets [22,23]. For instance, miR-96 is upregulated in breast cancer and promotes breast cancer metastasis by suppressing MTSS1 [24].…”

Section: Discussionmentioning

confidence: 99%

miR-96 regulates liver tumor-initiating cells expansion by targeting TP53INP1 and predicts Sorafenib resistance

Huang

Zhang

et al. 2020

J. Cancer

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Liver tumor-initiating cells (T-ICs) contribute to tumorigenesis, progression, recurrence and drug resistance of hepatocellular carcinoma (HCC). However, the underlying mechanism for the propagation of liver TICs remains unclear. In the present study, our finding shows that miR-96 is upregulated in liver TICs. Functional studies revealed that forced miR-96 promotes liver TICs self-renewal and tumorigenesis. Conversely, knockdown miR-96 inhibits liver TICs self-renewal and tumorigenesis. Mechanistically, miR-96 downregulates TP53INP1 via its mRNA 3'UTR in liver TICs. Furthermore, the miR-96 expression determines the responses of hepatoma cells to sorafenib treatment. Analysis of patient cohorts and patient-derived xenografts (PDXs) further demonstrate that the miR-96 may predict sorafenib benefits in HCC patients. Our findings revealed the crucial role of the miR-96 in liver TICs expansion and sorafenib response, rendering miR-96 as an optimal target for the prevention and intervention of HCC.

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miRNAs Expressions and Interaction with Biological Systems in Patients with Alzheimer`s Disease. Using miRNAs as a Diagnosis and Prognosis Biomarker

Abstract: For the evaluation and non-invasive monitoring of patients with Alzheimer`s disease the expression of miRNAs can be successfully used.

Cited by 11 publications

References 0 publications

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Retracted Article: Long non-coding RNA KCNQ1OT1 regulates cell proliferation, apoptosis and chemo-sensitivity through modulating the miR-186-5p/NCAM1 axis in acute myeloid leukemia cells

miR-96 regulates liver tumor-initiating cells expansion by targeting TP53INP1 and predicts Sorafenib resistance

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