MiRNAs as biomarkers for diagnosis of neonatal sepsis: a systematic review and meta-analysis

Han, Wenxiao; Li, Shangbin; Wang, Na; Chen, Xinqing; Ma, Jinjin; Liang, Jiaojiao; Hao, Ling; Ren, Changjun

doi:10.1080/14767058.2023.2217317

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Several miRNAs have been investigated as diagnostic markers in neonatal sepsis, encompassing both EOS and LOS. A recent systematic review and meta-analysis indicated the beneficial role of miRNA detection in neonatal sepsis diagnosis, with a pooled specificity of 0.76 and pooled sensitivity of 0.83, demonstrating relatively high overall accuracy [60]. In this study, the pooled diagnostic odds ratio was 15.81, which is close to that of traditional markers.…”

Section: Micrornas In Eossupporting

confidence: 69%

Application of Advanced Molecular Methods to Study Early-Onset Neonatal Sepsis

Kosmeri,

Giapros,

Serbis

et al. 2024

IJMS

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Early-onset sepsis (EOS) is a global health issue, considered one of the primary causes of neonatal mortality. Diagnosis of EOS is challenging because its clinical signs are nonspecific, and blood culture, which is the current gold-standard diagnostic tool, has low sensitivity. Commonly used biomarkers for sepsis diagnosis, including C-reactive protein, procalcitonin, and interleukin-6, lack specificity for infection. Due to the disadvantages of blood culture and other common biomarkers, ongoing efforts are directed towards identifying innovative molecular approaches to diagnose neonates at risk of sepsis. This review aims to gather knowledge and recent research on these emerging molecular methods. PCR-based techniques and unrestricted techniques based on 16S rRNA sequencing and 16S–23S rRNA gene interspace region sequencing offer several advantages. Despite their potential, these approaches are not able to replace blood cultures due to several limitations; however, they may prove valuable as complementary tests in neonatal sepsis diagnosis. Several microRNAs have been evaluated and have been proposed as diagnostic biomarkers in EOS. T2 magnetic resonance and bioinformatic analysis have proposed potential biomarkers of neonatal sepsis, though further studies are essential to validate these findings.

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Section: Micrornas In Eossupporting

confidence: 69%