miRNAs and lncRNAs: Potential Non-Invasive Biomarkers for Endometriosis

Maier, Ioana Maria; Maier, Adrian Cornel

doi:10.3390/biomedicines9111662

Cited by 14 publications

(12 citation statements)

References 77 publications

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“…miRNAs have entered the horizon as potential diagnostic markers for diseases, and circulating miRNAs in plasma and serum are recommended as non-invasive biomarkers for EMs. Many miRNAs have been found to be differentially expressed between EMs and healthy tissues, including miR-138, miR-199-5p, miR-20a, miR-34c, and miR-449 (Bjorkman and Taylor, 2019;Vanhie et al, 2019;Maier and Maier, 2021), which is consistent with our prediction and confirms the reliability of our study. Additionally, our study identified several miRNAs, whose association with EMs has not been previously reported in relevant studies.…”

Section: Discussionsupporting

confidence: 92%

Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis

Sun

2022

Front. Genet.

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Endometriosis (EMs), one of the most common gynecological diseases, seriously affects the health and wellness of women; however, the underlying pathogenesis remains unclear. This study focused on dysregulated genes and their predicted transcription factors (TFs) and miRNAs, which may provide ideas for further mechanistic research. The microarray expression dataset GSE58178, which included six ovarian endometriosis (OE) samples and six control samples, was downloaded from the Gene Expression Omnibus (GEO) to identify differentially expressed genes (DEGs). Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to study the cellular and organism-level functions of DEGs. The protein-protein interaction (PPI) network was built and visualized using Cytoscape, and modules and hub genes were explored using various algorithms. Furthermore, we predicted miRNAs and TFs of hub genes using online databases, and constructed the TF-miRNA-hub gene network. There were 124 upregulated genes and 66 downregulated genes in EMs tissues. GO enrichment analysis showed that DEGs were concentrated in reproductive structure development and collagen-containing extracellular matrix, while KEGG pathway analysis showed that glycolysis/gluconeogenesis and central carbon metabolism in cancer require further exploration. Subsequently, HIF1A, LDHA, PGK1, TFRC, and CD9 were identified as hub genes, 22 miRNAs and 34 TFs were predicted to be upstream regulators of hub genes, and these molecules were pooled together. In addition, we found three key feedback loops in the network, MYC-miR-34a-5p-LDHA, YY1-miR-155-5p-HIF1A, and RELA-miR-93-5p-HIF1A, which may be closely related to OE development. Taken together, our study structured a TF-miRNA-hub gene network to decipher the molecular mechanism of OE, which may provide novel insights for clinical diagnosis and treatment.

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Section: Discussionsupporting

confidence: 92%

Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis

Sun

2022

Front. Genet.

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“…It is well documented that miRNA expression in the human endometrium is dependent on the menstrual cycle phase and is regulated by sex steroids [ 106 ]. A broad range of different miRNAs involved in the pathogenesis of endometriosis and ectopic pregnancy has been described and they are summarized in Figure 3 [ 35 , 106 , 107 , 108 ]. In this part of the review, we focus on miRNAs that may constitute a link between these two diseases.…”

Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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Endometriosis is a common inflammatory disease characterized by the presence of endometrial cells outside the uterine cavity. It is estimated that it affects 10% of women of reproductive age. Its pathogenesis covers a wide range of abnormalities, including adhesion, proliferation, and cell signaling disturbances. It is associated with a significant deterioration in quality of life as a result of chronic pelvic pain and may also lead to infertility. One of the most serious complications of endometriosis is an ectopic pregnancy (EP). Currently, the exact mechanism explaining this phenomenon is unknown; therefore, there are no effective methods of prevention. It is assumed that the pathogenesis of EP is influenced by abnormalities in the contraction of the fallopian tube muscles, the mobility of the cilia, and in the fallopian microenvironment. Endometriosis can disrupt function on all three levels and thus contribute to the implantation of the embryo beyond the physiological site. This review takes into account aspects of the molecular mechanisms involved in the pathophysiology of endometriosis and EP, with particular emphasis on the similarities between them.

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“…In comparison to healthy controls, most lncRNAs are found in patients with malignant tumors [ 25 , 49 ]. Due to high expression levels of lncRNAs in tumors, lncRNAs can be found in body fluids such as blood, saliva, and plasma, suggesting that circulating lncRNAs may be employed as non-invasive tools for diagnosis of various cancers, including HCC [ 25 , 49 , 131 , 132 ].…”

Section: Cancer-associated Lncrnasmentioning

confidence: 99%

Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials

Khan

Zhang

2022

Bioengineering

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Hepatocellular carcinoma (HCC) is the most common and serious type of primary liver cancer. HCC patients have a high death rate and poor prognosis due to the lack of clear signs and inadequate treatment interventions. However, the molecular pathways that underpin HCC pathogenesis remain unclear. Long non-coding RNAs (lncRNAs), a new type of RNAs, have been found to play important roles in HCC. LncRNAs have the ability to influence gene expression and protein activity. Dysregulation of lncRNAs has been linked to a growing number of liver disorders, including HCC. As a result, improved understanding of lncRNAs could lead to new insights into HCC etiology, as well as new approaches for the early detection and treatment of HCC. The latest results with respect to the role of lncRNAs in controlling multiple pathways of HCC were summarized in this study. The processes by which lncRNAs influence HCC advancement by interacting with chromatin, RNAs, and proteins at the epigenetic, transcriptional, and post-transcriptional levels were examined. This critical review also highlights recent breakthroughs in lncRNA signaling pathways in HCC progression, shedding light on the potential applications of lncRNAs for HCC diagnosis and therapy.

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miRNAs and lncRNAs: Potential Non-Invasive Biomarkers for Endometriosis

Cited by 14 publications

References 77 publications

Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis

Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials

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