miRNA targeted signaling pathway in the early stage of denervated fast and slow muscle atrophy

Li, Gang; Liu, Qingshan; Li, Wenbin; Wei, Jian Jun; Wenkai, Chang; Chen, Zhi; Qiao, Hu-yun; Jia, Yingwei; Tian, Jun; Liang, Bing-sheng

doi:10.4103/1673-5374.189195

Cited by 27 publications

(22 citation statements)

References 57 publications

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“…That miR‐206 is elevated in the TA but not the GA strengthens this finding's significance. Levels of miR‐206 depend on the relative proportion of fast‐ and slow‐fibre composition; elevation is associated with muscles predominantly composed of fast‐type fibres; decrease, with slow‐type fibres; and no change with mixed fibre‐type composition . Since myomiRs are expressed in both cardiac and skeletal muscle, but miR‐206 is skeletal muscle‐specific, so its serum levels reflect the balance between myofibre expression and the magnitude of extrusion to circulation.…”

Section: Discussionmentioning

confidence: 99%

The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability

et al. 2018

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Aim: Symptoms of autonomic failure are frequently the presentation of advanced age and neurodegenerative diseases that impair adaptation to common physiologic stressors. The aim of this work was to examine the interaction between the sympathetic and motor nervous system, the involvement of the sympathetic nervous system (SNS) in neuromuscular junction (NMJ) presynaptic motor function, the stability of postsynaptic molecular organization, and the skeletal muscle composition and function. Methods: Since muscle weakness is a symptom of diseases characterized by autonomic dysfunction, we studied the impact of regional sympathetic ablation on muscle motor innervation by using transcriptome analysis, retrograde tracing of the sympathetic outflow to the skeletal muscle, confocal and electron microscopy, NMJ transmission by electrophysiological methods, protein analysis, and state of the art microsurgical techniques, in C57BL6, MuRF1KO and Thy-1 mice. Results: We found that the SNS regulates motor nerve synaptic vesicle release, skeletal muscle transcriptome, muscle force generated by motor nerve activity, axonal neurofilament phosphorylation, myelin thickness, and myofibre subtype composition and CSA. The SNS also modulates the levels of postsynaptic membrane acetylcholine receptor by regulating the Gα i2 -Hdac4-Myogenin-MuRF1pathway, which is prevented by the overexpression of the guanine nucleotide-binding protein Gα i2 (Q205L), a constitutively active mutant G protein subunit.Rodrigues, Messi and Wang are contributed equally to this work.

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Section: Discussionmentioning

confidence: 99%

The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability

et al. 2018

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“…The nerve injury usually complicates with a few symptoms, such as diabetic neuropathy, degenerative disc disease, SMA, trauma, alcoholic neuropathy, viral infection, and the cancers (Hsieh et al, 2011;Tamura et al, 2015). Therefore, when the symptoms of muscle denervation combining with several SMA-associated factors, DSMA is induced and causes the irreversible dysfunction of muscles, which can't be rescued with any treatment clinically (Huang et al, 2016;Li et al, 2016). Although there have been applied several therapeutic methods for treating DSMA nowadays (Huang et al, 2016;Romeo-Guitart et al, 2017), the therapeutic effects are also unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

Herbal complex 'Buyang Huanwu Tang' improves motor endplate function of denervated-dependent skeletal muscle atrophy in rat

Zhou

Huang

Xie

et al. 2020

Journal of Integrative Neuroscience

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“…It has been demonstrated that myomiRs play a key role in the proliferation, differentiation, and diseases of skeletal muscle [ 11 , 12 ]. A number of miRNAs are differentially expressed and are highly involved in the pathophysiological process of denervated muscles [ 13 ]. Moreover, it has been reported that miRNAs have been found in a number of body fluids including serum [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Serum miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy

Wang

et al. 2017

BioMed Research International

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Muscle biopsy has long been expected to be replaced by noninvasive biomarkers with diagnostic value and prognostic applications for muscle atrophy. Growing evidence suggests that circulating microRNAs (miRNAs) could act as biomarkers for numerous pathophysiological statuses. In the present study, our results showed that the serum levels of six muscle-specific miRNAs (miR-1/23a/133/206/208b/499) were all elevated in unloading induced mice. The medium levels of these six muscle-specific miRNAs were all elevated in starvation induced atrophic C2C12 myotubes. Moreover, the serum levels of miR-23a/206/499 were induced in participants after 45 days of head-down bed rest (HDBR). The levels of miR-23a/206/499 were positively correlated with the ratio of soleus volume loss in HDBR participants, indicating that they might represent the process of muscle loss. In conclusion, our results demonstrated that circulating miRNAs could serve as useful biochemical and molecular indicators for muscle atrophy diagnosis and disease progression.

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miRNA targeted signaling pathway in the early stage of denervated fast and slow muscle atrophy

Cited by 27 publications

References 57 publications

The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability

The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability

Herbal complex 'Buyang Huanwu Tang' improves motor endplate function of denervated-dependent skeletal muscle atrophy in rat

Serum miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy

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