miRNA oligonucleotide and sponge for miRNA-21 inhibition mediated by PEI-PLL in breast cancer therapy

Gao, Shiqian; Tian, Huayu; Guo, Yifeng; Li, Yuce; Guo, Zhaopei; Zhu, Xuemei; Chen, Xuesi

doi:10.1016/j.actbio.2015.07.020

Cited by 96 publications

(51 citation statements)

References 31 publications

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“…Many strategies, such as PEGylation, bonding PEI with functional groups and synthesis of biodegradable PEIs through crosslinking or grafting, have been introduced to reduce cytotoxicity and promote the transfection efficiency of PEI [74]. High positive charge of PEI can result in electrostatic interactions with biological molecules with negative charge (nucleic acids or proteins) and thus facilitate cellular uptake (Figure 5) [75]. However, the non-degradability of PEI has limited its applications in vivo [76].…”

Section: Cellular Toxicity and Transfection Ability Of Peimentioning

confidence: 99%

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

Zakeri

Kouhbanani

Beheshtkhoo

et al. 2018

Nano Reviews & Experiments

225

150

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The meaning of gene therapy is the delivery of DNA or RNA to cells for the treatment or prevention of genetic disorders. The success rate of gene therapy depends on the progression and safe gene delivery system. The vectors available for gene therapy are divided into viral and non-viral systems. Viral vectors cause higher transmission efficiency and long gene expression, but they have major problems, such as immunogenicity, carcinogenicity, the inability to transfer large size genes and high costs. Non-viral gene transfer vectors have attracted more attention because they exhibit less toxicity and the ability to transfer large size genes. However, the clinical application of non-viral methods still faces some limitations, including low transmission efficiency and poor gene expression. In recent years, numerous methods and gene-carriers have been developed to improve gene transfer efficiency. The use of Polyethylenimine (PEI) based transfer of collaboration may create a new way of treating diseases and the combination of chemotherapy and gene therapy. The purpose of this paper is to introduce the PEI as an appropriate vector for the effective gene delivery.

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Section: Cellular Toxicity and Transfection Ability Of Peimentioning

confidence: 99%

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

Zakeri

Kouhbanani

Beheshtkhoo

et al. 2018

Nano Reviews & Experiments

225

150

View full text Add to dashboard Cite

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“…For example, miRNA sponges designed for modulation of miR-10b, miR-21, miR-155 and miR-221/222 mediate an impact on the activity of many protein targets, such as HOXD-10, PDCD4, Smad4, SRC3, Bcl-2 Bim, FOXO3a, PTEN and RhoA. Thus they provide inhibition of proliferation, activation of apoptosis and increase in the sensitivity of tumour cells to chemotherapy [28][29][30]. Suppression of oncogenic activity of miR-522 in a non-small cell lung M A N U S C R I P T…”

Section: Introductionmentioning

confidence: 99%

miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells

et al. 2017

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Please cite this article as: Patutina OA, Bichenkova EV, Miroshnichenko SK, Mironova NL, Trivoluzzi LT, Burusco KK, Bryce RA, Vlassov VV, Zenkova MA, miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells, Biomaterials (2017Biomaterials ( ), doi: 10.1016Biomaterials ( / j.biomaterials.2017 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…In terms of tumor-targeted delivery, a suitable delivery system is required that helps this combination escape from the recognition of macrophage systems, penetrate into tumor tissues, and accumulate in their intracellular sites of action. In recent years, significant progress in combination therapy has been made with cationic nanoparticles formed with liposomes, 26,27 polymers, 28,29 micelles, 30,31 and dendrimers. 29 Among these, endogenous lipoproteins have attracted growing attention, due to their advantages, such as ease of formulation, excellent biocompatibility, and clinical potential.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, significant progress in combination therapy has been made with cationic nanoparticles formed with liposomes, 26,27 polymers, 28,29 micelles, 30,31 and dendrimers. 29 Among these, endogenous lipoproteins have attracted growing attention, due to their advantages, such as ease of formulation, excellent biocompatibility, and clinical potential. High-density lipoprotein (HDL), which is composed of anionic Apo AI and phospholipids, has shown great potential in biomedical applications, including controlled release, target-specific …”

Section: Introductionmentioning

confidence: 99%

Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells

Rui¹,

Qu²,

Gao³

et al. 2016

IJN

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miRNA oligonucleotide and sponge for miRNA-21 inhibition mediated by PEI-PLL in breast cancer therapy

Cited by 96 publications

References 31 publications

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells

Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells

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