Abstract:Background: The aim of this study was to investigate whether miRNA levels in the circulation could serve as a predictive biomarker for responsiveness to anti-vascular endothelial growth factor (VEGF) therapy in patients with diabetic macular edema. Methods: Whole blood samples were collected at baseline from 135 patients who were included in the BRDME study, a randomized controlled comparative trial of monthly bevacizumab or ranibizumab treatment for 6 months in patients with diabetic macular edema (Trialregis… Show more
“…Their findings suggest that miR-181a may be negatively associated with the central area thickness of the retina at baseline. Work focused on miRs is emerging, and it is exciting to think similar trends can be determined as we identify more systemic biomarker candidates [12].…”
“…Their findings suggest that miR-181a may be negatively associated with the central area thickness of the retina at baseline. Work focused on miRs is emerging, and it is exciting to think similar trends can be determined as we identify more systemic biomarker candidates [12].…”
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