miRNA/epithelial-mesenchymal axis (EMT) axis as a key player in cancer progression and metastasis: A focus on gastric and bladder cancers

Sahib, Ameer S.; Fawzi, Amjid; Zabibah, Rahman S.; Koka, Nisar Ahmad; Khudair, Shaymaa Abdulhameed; Muhammad, Faris Anad; Hamad, Doaa A.

doi:10.1016/j.cellsig.2023.110881

Cellular Signalling

2023

DOI: 10.1016/j.cellsig.2023.110881

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miRNA/epithelial-mesenchymal axis (EMT) axis as a key player in cancer progression and metastasis: A focus on gastric and bladder cancers

Ameer S. Sahib,

Amjid Fawzi,

Rahman S. Zabibah

et al.

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Cited by 2 publications

References 274 publications

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Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance

Zhang,

Gao,

Fang

et al. 2024

Cancer Metastasis Rev

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Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance

Zhang,

Gao,

Fang

et al. 2024

Cancer Metastasis Rev

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Survival and Enrichment Analysis of Epithelial–Mesenchymal Transition Genes in Bladder Urothelial Carcinoma

Ali,

Xiao,

Jacobs

et al. 2023

Genes

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The escalating prevalence of bladder cancer, particularly urothelial carcinoma, necessitates innovative approaches for prognosis and therapy. This study delves into the significance of genes related to epithelial–mesenchymal transition (EMT), a process inherently linked to carcinogenesis and comparatively better studied in other cancers. We examined 1184 EMT-related gene expression levels in bladder urothelial cancer cases through the TCGA dataset. Genes shown to be differentially expressed in relation to survival underwent further network and enrichment analysis to uncover how they might shape disease outcomes. Our in silico analysis revealed a subset of 32 genes, including those significantly represented in biological pathways such as VEGF signaling and bacterium response. In addition, these genes interact with genes involved in the JAK-STAT signaling pathway. Additionally, some of those 32 genes have been linked to immunomodulators such as chemokines CCL15 and CCL18, as well as to various immune cell infiltrates. Our findings highlight the prognostic utility of various EMT-related genes and identify possible modulators of their effect on survival, allowing for further targeted wet lab research and possible therapeutic intervention.

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miRNA/epithelial-mesenchymal axis (EMT) axis as a key player in cancer progression and metastasis: A focus on gastric and bladder cancers

Cited by 2 publications

References 274 publications

Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance

Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance

Survival and Enrichment Analysis of Epithelial–Mesenchymal Transition Genes in Bladder Urothelial Carcinoma

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