miRNA‑770‑5p expression is upregulated in patients with type 2 diabetes and miRNA‑770‑5p knockdown protects pancreatic β‑cell function via targeting BAG5 expression

MiRNA-30d and miR-770-5p as potential clinical risk predictors of Vasoplegic Syndrome in Patients undergoing on-pump coronary artery bypass grafting

“…This information could suggest that miRNA-30d might also play a similar role in VS, regulating the inflammatory response and endothelial gene expression dysregulation. MiRNA-770 was previously shown to be associated in regulation of apoptosis and cell proliferation 19 and in different disease states as in diabetes 20 , dilated cardiomyopathy 21 , and different types of cancers 19 , such as non-small cell lung 22 , breast 23 and gastric cancer 24 . Here, we show, by computational prediction analyses, that the dysregulated miRNAs have a potential role in controlling targets related to the apelinergic system, responsible for signaling events related to severe and refractory hypotension, a common outcome in patients who progress to VS 25 .…”

“…This information could suggest that miRNA-30d might also play a similar role in VS, regulating the inflammatory response and endothelial gene expression dysregulation. MiRNA-770 was previously shown to be associated in regulation of apoptosis and cell proliferation 19 and in different disease states as in diabetes 20 , dilated cardiomyopathy 21 , and different types of cancers 19 , such as non-small cell lung 22 , breast 23 and gastric cancer 24 .…”

MiRNA dysregulation underlying common pathways in type 2 diabetes and cancer development: an Italian Association of Medical Oncology (AIOM)/Italian Association of Medical Diabetologists (AMD)/Italian Society of Diabetology (SID)/Italian Society of Endocrinology (SIE)/Italian Society of Pharmacology (SIF) multidisciplinary critical view

“… 15 , 41 Similarly, miR-187, miR-124a, and miR-770-5p expression is increased in human T2D islets and negatively correlated with β-cell function. 42 , 43 , 44 Similarly, the transient overexpression of miR-29a negatively affects GSIS in MIN6 cells. 45 On the contrary, miR-125b-5p is down-regulated in β-cells of diabetic mice and this results in reduced insulin sensitivity and deregulated β-cell function.…”

“… 23 miR-770-5p Promotes β-cell dysfunction and death. 44 ER, endoplasmic reticulum; GLP-1, glucagon-like peptide-1; GSIS, glucose-stimulated insulin secretion; miRNA, microRNA; mRNA, messenger RNA; ROS, reactive oxygen species. …”

“… 45 Likewise, miR-124a and miR-770-5p expression is increased in patients with T2D and promotes β-cell death. 43 , 44 In addition, many miRNAs can also affect the maturity state of β-cells: for example, the miR-29 family, miR-204, and miR-129 are up-regulated, whereas the miR-17-92 cluster, miR-181b, and miR-215 are suppressed, in young, immature, proliferating islets compared to adult, mature, non-proliferating islets. 15 In particular, the miR-17-92 cluster and miR-181b are able to regulate both β-cell replication and GSIS.…”