miRNA‑7515 suppresses pancreatic cancer cell proliferation, migration and invasion via downregulating IGF‑1 expression

Abstract

Pancreatic cancer (PC) is a lethal malignancy of the gastrointestinal tract. Previous studies have reported that microRNAs (miRNAs/miRs) are involved in the tumorigenesis of PC. Therefore, the present study aimed to determine the effects of miR-7515 on PC cell proliferation, invasion and migration in vitro and in vivo, and investigate its underlying molecular mechanism using bioinformatics, double luciferase assay and western blotting. The results revealed that the expression levels of miR-7515 were downregulated in PC, which predicted a poor clinical outcome. The overexpression of miR-7515 significantly decreased the proliferation, invasive and migratory abilities of PC cells in vitro and in vivo, while the knockdown of miR-7515 exerted the opposite effects.

Inhibition of ALDOA‐ and ENO1‐Mediated Glycolysis of Oridonin as a Novel Antitumor Strategy of Non‐Small‐Cell Lung Cancer

“…[ 55 ] Previous studies have indicated that oxidative stress induced by PPARγ activation is mainly responsible for cancer inhibition. [ 56–58 ] In this study, we found that ORI significantly downregulated ALDOA, ENO1, and IGF‐1, whereas upregulated PPARγ protein expression at the cellular level. A more convincing manifestation was that the inhibitory effect of ORI was still present after siRNA interfered with the expression of ALDOA and ENO1.…”

CircCEP85 upregulates IGF1 expression to promote breast cancer progression via sponging miR-1193

“…IGF-1 is a polypeptide hormone belonging to the growth factor hormone family that helps control the growth and development of organs, muscles, and tissues in the body, besides, it is also involved in regulating glucose metabolism and brain function, IGF-1 assists with natural bodily development, while abnormal accumulation of IGF-1 can negatively affect health [25]. Currently, IGF1 was found to be involved in many cancers, such as lung cancer [26], cervical cancer [27], pancreatic cancer [28], and esophageal carcinoma [29]. In breast cancer, IGF-1 gene polymorphism was associated with an increased risk for this cancer [30].…”