miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus

Han, Qingjian; Liu, Di; Convertino, Marino; Wang, Zilong; Jiang, Changyu; Kim, Yong Ho; Luo, Xin; Zhang, Xin; Nackley, Andrea G.; Dokholyan, Nikolay V.; Ji, Ru Rong

doi:10.1016/j.neuron.2018.06.039

Cited by 87 publications

(93 citation statements)

References 60 publications

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“…Great progress has been made in elucidating itch’s neuronal mechanisms, including peripheral and central mechanisms of itch (Dong and Dong, 2018; Sun and Chen, 2007). Chronic itch is associated with benign skin lesions or cancers such as lymphoma (Han et al, 2018; Yosipovitch and Bernhard, 2013). Distinct mechanisms have been implicated in acute itch and chronic itch(Liu and Ji, 2013).…”

Section: Emerging Role Of Microglia In Chronic Itchmentioning

confidence: 99%

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

Chen

Zhang

Qadri

et al. 2018

Neuron

Self Cite

553

459

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The previous decade has seen a rapid increase in microglial studies on pain, with a unique focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis. We highlight that microglial mediators such as pro- and anti-inflammatory cytokines are powerful neuromodulators that regulate synaptic transmission and pain via neuron-glial interactions. We also reveal an emerging role of microglia in the resolution of pain, in part via specialized pro-resolving mediators including resolvins, protectins and maresins. We also discuss a possible role of microglia in chronic itch.

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Section: Emerging Role Of Microglia In Chronic Itchmentioning

confidence: 99%

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

Chen

Zhang

Qadri

et al. 2018

Neuron

Self Cite

553

459

View full text Add to dashboard Cite

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“…PARs are activated by endogenous and exogenous proteases on keratinocytes and sensory nerve endings (26). Activation of PARs can be linked to downstream activation of transient receptor potential (TRP) vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively) (27); a large variety of inflammatory mediators also directly activate these TRP channels (28,29).…”

Section: Mechanisms Of Itchmentioning

confidence: 99%

Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions

Yosipovitch¹,

Miséry²,

Proksch³

et al. 2019

Acta Derm Venereol

112

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Itch is a common symptom of many skin barrier-related dermatoses and can severely impact quality of life. However, there are a limited number of effective anti-itch topical therapies currently available and several unmet needs not addressed by current itch management strategies. As our knowledge of the mechanisms underlying itch has improved, several novel therapies have recently emerged that can be incorporated into existing regimens to enhance itch therapy and management. Here, we summarise research and current opinion on available topical therapies and give recommendations for the optimal management of itch. Barrier damage, dry skin and itch are intricately linked and form the basis of many common skin diseases. Damage from environmental insults, or genetic or inflammatory causes, can impair the skin barrier, resulting in an increase in transepidermal water loss and activation of itch-associated nerve fibres. The itch-scratch cycle can perpetuate skin barrier damage and itch. Topical therapeutic strategies are utilised to overcome dry skin and itch, primarily in the form of emollients. Recent advances in our understanding of the mechanisms underlying itch have enabled the development of new topical therapies, which may be incorporated into existing treatment regimes. Ultimately, treatment of dry skin and itch must be highly tailored to the individual according to their needs.

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“…Chronic itch is a major symptom of cutaneous T cell lymphoma [58]. Intradermal inoculation of human Myla cells can induce lymphoma associated with intense itching in immune-deficient mice [59]. Interestingly, lymphoma-associated itch is suppressed by a miRNA-711 inhibitor and a blocking peptide that disrupts miRNA-711/TRPA1 interaction.…”

Section: Trp Channels and Itch Signalingmentioning

confidence: 99%

TRP Channels as Drug Targets to Relieve Itch

Xie

2018

Pharmaceuticals

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Although acute itch has a protective role by removing irritants to avoid further damage, chronic itch is debilitating, significantly impacting quality of life. Over the past two decades, a considerable amount of stimulating research has been carried out to delineate mechanisms of itch at the molecular, cellular, and circuit levels. There is growing evidence that transient receptor potential (TRP) channels play important roles in itch signaling. The purpose of this review is to summarize our current knowledge about the role of TRP channels in the generation of itch under both physiological and pathological conditions, thereby identifying them as potential drug targets for effective anti-itch therapies.

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miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus

Cited by 87 publications

References 60 publications

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions

TRP Channels as Drug Targets to Relieve Itch

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