miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline

Kao, Yu-Chia; Wang, I-Fang; Tsai, Kuen‐Jer

doi:10.3390/ijms19082323

Cited by 28 publications

(16 citation statements)

References 47 publications

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“…Among the mechanisms proposed to explain the miR‐34a and miR‐34c effects on memory impairment are the decreased expression of sirtuin‐1 (Bhatnagar et al, 2014; Li et al, 2011). In addition, overexpression of miR‐34c in hippocampal neurons negatively regulated dendritic outgrowth (Kao et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Alcohol Use Disorder is Associated with Upregulation of MicroRNA‐34a and MicroRNA‐34c in Hippocampal Postmortem Tissue

Santos‐Bezerra

Cavaleiro

Santos

et al. 2021

Alcoholism Clin & Exp Res

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Background To investigate epigenetic mechanisms potentially involved in the cognitive decline associated with chronic alcohol intake, we evaluated the expressions of three micro‐RNAs (miR‐34a, ‐34b, and ‐34c) highly expressed in the hippocampus and involved in neuronal physiology and pathology. MiR‐34a participates in functioning and survival of mature neurons; miR‐34b is associated with Alzheimer‐like disorders; and miR‐34c is implicated in the memory impairment of Alzheimer disease in rodents and humans. Methods A total of 69 cases were selected from the Biobank for Aging Studies and categorized according to the absence (n = 50) or presence (n = 19) of alcohol use disorder (AUD). Cases presenting with neuropathological diagnoses of dementias were excluded. Total RNA was extracted from hippocampal paraffinized slices, complementary DNA was synthesized from miRs, and RT‐qPCR was performed with TaqMan® assays. Results Higher expressions of miR‐34a and miR‐34c, but not of miR‐34b, were found in the group with AUD in comparison with the group without AUD after adjustment for potential confounders (age, sex, body mass index, presence of hypertension, diabetes mellitus, smoking, and physical inactivity). Conclusions Hippocampal upregulation of miR‐34a and miR‐34c may be involved in the cognitive decline associated with chronic alcohol consumption.

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Section: Discussionmentioning

confidence: 99%

Alcohol Use Disorder is Associated with Upregulation of MicroRNA‐34a and MicroRNA‐34c in Hippocampal Postmortem Tissue

Santos‐Bezerra

Cavaleiro

Santos

et al. 2021

Alcoholism Clin & Exp Res

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“…Many miRNAs have been identified as key elements for the regulation of cognitive functions and memory processes lost in AD, through the regulation of activity-mediated protein synthesis at the synaptic level (Ramakrishna and Muddashetty, 2019). Mice overexpressing the miR-34c are characterized by reduced dendritic length and spine density (Kao et al, 2018). In an AD mouse model (Tg2576 mice), it was found that miR-124 is dramatically increased in the hippocampus and is directly associated with deficits in synaptic plasticity and memory dysfunction (Wang et al, 2018).…”

Section: Micrornas’ Involvement In Alzheimer’s Diseasementioning

confidence: 99%

MicroRNAs in Alzheimer’s Disease: Diagnostic Markers or Therapeutic Agents?

et al. 2019

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MicroRNAs (miRNAs) are small non-coding nucleic acids able to post-transcriptionally regulate gene expression by binding to complementary sequences of target messenger RNA (mRNA). It has been estimated that at least 1% of the human genome encodes miRNA and every miRNA can regulate up to 200 mRNAs. These findings suggest that dysregulation of miRNA expression could be associated with several human pathological conditions including central neurological disorders. Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. The characteristic symptoms are a progressive loss of memory and other cognitive functions due to the impairment of particular types of neurons and synapses, leading to neuronal death. At present, the available symptomatic treatments can only slow down disease progression without stopping it. miRNAs are widely found within the nervous system where they are key regulators of functions such as neurite outgrowth, dendritic spine morphology, neuronal differentiation, and synaptic plasticity. This has been the clue for considering miRNAs crucial molecules to be studied in AD, and nowadays, dysfunction of miRNAs in AD is increasingly recognized. In this review, we summarized existing evidence about miRNAs as biomarkers or therapeutic agents. The field of miRNAs as biomarkers is more advanced in terms of human data, and it is likely that miRNAs will be used successfully in the near future. Given the huge number of miRNAs potentially involved in diagnostics, miRNA panels will be used for specific tasks such as the stage of the disease, the risk prediction, and disease progression. The field of miRNAs as therapeutics is rapidly developing, and it offers a huge variety of solutions. These include positive effects related to beta-amyloid or tau reduction, increased number of neurons, inhibition of apoptosis, protection of synapses, transformation of other cellular elements into missing/deficient neurons in AD, and so on. It is predictable that both areas of research will be carried forward. However, given the absence of an AD therapy able to stop or reverse the disease, it is desirable to accelerate research on miRNAs as therapeutic agents.

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“…Moreover, overexpression of miR‐34c perturbs dendritic outgrow and diminishes the number of dendritic spine and filopodia. From the above‐mentioned document, miR‐34c could be considered as a therapeutic target correlating to AD‐linked cognitive deficit (Kao, Wang, & Tsai, 2018). miRNA‐125b is one of the raised miRNAs in the brain of patients with AD.…”

Section: Neurological Disorders Associated With Cognitive Impairmentmentioning

confidence: 99%

MicroRNA alterations in neuropathologic cognitive disorders with an emphasis on dementia: Lessons from animal models

Bahlakeh

Gorji

Soltani

et al. 2020

Journal Cellular Physiology

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Cognitive dysfunction is a state of losing or having difficulties in remembering, learning, focusing, or making decisions that impact individual healthy life. Small single-stranded and nonprotein coding RNAs, microRNAs (miRNAs) participate actively in regulatory processes, incorporate cognitive signaling pathways, and intensely affect cognitive evolution. miRNAs exert their modification activities through translational or transcriptional processes. Reportedly, cognitive impairment and dementia are rising, especially in developing countries. Herein we provided a brief review of original studies addressing miRNA changes in the most common neurological diseases with a focus on dementia and Alzheimer's disease. It must be How to cite this article: Bahlakeh G, Gorji A, Soltani H, Ghadiri T. MicroRNA alterations in neuropathologic cognitive disorders with an emphasis on dementia: Lessons from animal models.

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miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline

Cited by 28 publications

References 47 publications

Alcohol Use Disorder is Associated with Upregulation of MicroRNA‐34a and MicroRNA‐34c in Hippocampal Postmortem Tissue

Alcohol Use Disorder is Associated with Upregulation of MicroRNA‐34a and MicroRNA‐34c in Hippocampal Postmortem Tissue

MicroRNAs in Alzheimer’s Disease: Diagnostic Markers or Therapeutic Agents?

MicroRNA alterations in neuropathologic cognitive disorders with an emphasis on dementia: Lessons from animal models

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