MiRNA-196-5p Promotes Proliferation and Migration in Cholangiocarcinoma via HAND1/Wnt/β-Catenin Signaling Pathway

Liu, Chao; Li, Yanli; Zhang, Lichao; Zhang, Pei; Yu, Ning; Liu, Xuefang; Lu, Huaihai; Du, Haiming; Hou, Senlin

doi:10.1155/2022/4599676

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Although miR-205-5p has diverse effects in different malignancies, it is not known how it affects on CCA. The roles of other miRNAs in CCA have been reported previously: there is upregulation of miR-181b-5p 22 and miR-23a-3p 23 in human CCA tissues and of miR-196-5p in CCA cell lines 24 . On the other hand, miRNA-206 is downregulated in CCA cell lines 25 , miR-7-5p in intrahepatic CCA tissue and cell lines 26 , and miR-451 in human tissues and serum 27 in CCA patients compared with normal subjects.…”

Section: Introductionmentioning

confidence: 59%

Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3

Mon,

Intuyod,

Klungsaeng

et al. 2023

Sci Rep

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The microRNA miR-205-5p has diverse effects in different malignancies, including cholangiocarcinoma (CCA), but its effects on CCA progression is unclear. Here we investigated the role and function of miR-205-5p in CCA. Three CCA cell lines and human serum samples were found to have much higher expression levels of miR-205-5p than seen in typical cholangiocyte cell lines and healthy controls. Inhibition of miR-205-5p suppressed CCA cell motility, invasion and proliferation of KKU-213B whereby overexpression of miR-205-5p promoted cell proliferation and motility of KKU-100 cells. Bioinformatics tools (miRDB, TargetScan, miRWalk, and GEPIA) all predicted various miR-205-5p targets. Experiments using miR-205-5p inhibitor and mimic indicated that homeodomain-interacting protein kinase 3 (HIPK3) was a potential direct target of miR-205-5p. Overexpression of HIPK3 using HIPK3 plasmid cloning DNA suppressed migration and proliferation of KKU-100 cells. Notably, HIPK3 expression was lower in human CCA tissues than in normal adjacent tissues. High HIPK3 expression was significantly associated with longer survival time of CCA patients. Multivariate regression analysis indicated tissue HIPK3 levels as an independent prognostic factor for CCA patients. These findings indicate that overexpression of miR-205-5p promotes CCA cells proliferation and migration partly via HIPK3-dependent way. Therefore, targeting miR-205-5p may be a potential treatment approach for CCA.

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Section: Introductionmentioning

confidence: 59%

Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3

Mon,

Intuyod,

Klungsaeng

et al. 2023

Sci Rep

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“…The miR-196-5p can boost cell proliferation and migration in ICC pathogenesis via HAND1/Wnt/β-catenin signaling pathway 18 . These results demonstrated that miRNAs as important regulatory non-coding RNAs played pivotal roles in the progress and pathogenesis 19 . However, there are fewer reports to insight into the regulatory miRNA–mRNA networks in ICC pathogenesis.…”

Section: Introductionmentioning

confidence: 82%

Integration analysis of miRNA–mRNA expression exploring their potential roles in intrahepatic cholangiocarcinoma

Liu

Shi

Zhang

et al. 2023

Sci Rep

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Intrahepatic cholangiocarcinoma (ICC) is the second common primary hepatic malignancy tumor. In this study, an integrative analysis of differentially expressed genes (DEGs) and miRNAs from the ICC onset and adjacent normal tissues were performed to explore the regulatory roles of miRNA–mRNA interaction. A total of 1018 DEGs and 39 miRNAs were likely involved in ICC pathogenesis, suggesting the changes in cell metabolism in ICC development. The built network indicated that 30 DEGs were regulated by 16 differentially expressed miRNA. The screened DEGs and miRNA together were probably considered the biomarkers of ICC, and their important roles in ICC pathogenesis remain to be elucidated. This study could provide a good basis to uncover the regulatory mechanism of miRNA and mRNAs in ICC pathogenesis.

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Tumor Microenvironment Remodeling in Gastrointestinal Cancer: Role of miRNAs as Biomarkers of Tumor Invasion

et al. 2023

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Gastrointestinal (GI) cancers are the most frequent neoplasm, responsible for half of all cancer-related deaths. Metastasis is the leading cause of death from GI cancer; thus, studying the processes that regulate cancer cell migration is of paramount importance for the development of new therapeutic strategies. In this review, we summarize the mechanisms adopted by cancer cells to promote cell migration and the subsequent metastasis formation by highlighting the key role that tumor microenvironment components play in deregulating cellular pathways involved in these processes. We, therefore, provide an overview of the role of different microRNAs in promoting tumor metastasis and their role as potential biomarkers for the prognosis, monitoring, and diagnosis of GI cancer patients. Finally, we relate the possible use of nutraceuticals as a new strategy for targeting numerous microRNAs and different pathways involved in GI tumor invasiveness.

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MiRNA-196-5p Promotes Proliferation and Migration in Cholangiocarcinoma via HAND1/Wnt/β-Catenin Signaling Pathway

Cited by 3 publications

References 36 publications

Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3

Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3

Integration analysis of miRNA–mRNA expression exploring their potential roles in intrahepatic cholangiocarcinoma

Tumor Microenvironment Remodeling in Gastrointestinal Cancer: Role of miRNAs as Biomarkers of Tumor Invasion

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