miRNA-15/IL-10Rα axis promotes Kabasura Kudineer (Indian traditional Siddha formulation) induced immunomodulation by suppressing oxidative stress

Behera, Jyotirmaya; Kumar, Manish; Femela, A Ireen; Senguttuvan, G.; Ramasamy, M.S.

doi:10.1016/j.jep.2022.116032

Cited by 2 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For decades, hundreds of documents have elucidated the functional roles of non-coding RNAs (ncRNAs) in the formation of ARC. NcRNAs including microRNA, lncRNA, and circRNA have been reported to regulate apoptosis, oxidative stress, and ferroptosis in various diseases, which were also demonstrated in cataract formation, but the exact mechanism still remains unclear, thus lack clinical application [4][5][6]. Therefore, given the incomparable role of ncRNAs in the pathogenesis of ARC, there in an urgent need to further explore the molecular mechanisms of ARC, especially the regulatory roles of ncRNAs.…”

Section: Introductionmentioning

confidence: 99%

Identification of tRNA-derived small RNAs expression profiles and their potential functions in age-related cataract

Liu

Zhang

Jiang

et al. 2023

Preprint

View full text Add to dashboard Cite

Object: To identify the expression profiles and demonstrate the potential functions of tRNA-derived small RNAs (tsRNAs) in the formation of age-related cataract (ARC). Methods: Human lens epithelial cell line (HLE-B3 cells) were treated with H2O2, small RNA sequencing analysis was performed to identify expression profiles of tsRNAs in control and H2O2-treated HLE-B3 cells. Then, GO and KEGG enrichment analysis were employed to illustrate the potential functions of differentially expressed (DE) tsRNAs and target genes in ARC. Finally, quantitative real-time PCR assay was used to verify the expression patterns of DE tsRNAs. Results: Totally 604 DE tsRNAs (329 upregulated and 275 downregulated) were obtained between control and H2O2-treated HLE-B3 cells. Bioinformatic analysis results showed that calcium signaling pathway may mainly participate in the formation of ARC. Conclusion: Our results indicated that tsRNAs may be associated with the pathogenesis of ARC, and thus might be potential diagnostic and therapeutic targets for ARC.

show abstract

Section: Introductionmentioning

confidence: 99%