miRNA-143-3p-Sox6-Myh7 Pathway is Altered in Obesogenic Diet-Induced Cardiac Hypertrophy in Female Mice

Silva, Tábatha de Oliveira; Lino, Caroline Antunes; Miranda, Jarbas Honório de; Balbino-Silva, Camila S.; Lunardon, Guilherme; Lima, Vanessa Batista de Sousa; Jensen, Leonardo; Donato, José; Irigoyen, Maria Cláudia; Barreto‐Chaves, Maria Luíza Morais; Diniz, Gabriela Placoná

doi:10.2139/ssrn.3971787

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiRNA deregulation is frequent during CH 25 . As an example, miR-143-3p is related to the development of CH induced by an obesogenic diet 26 . Moreover, targeting miR-30b has been proposed as a potential therapy in CH 27 .…”

Section: Discussionmentioning

confidence: 99%

CircRNA Larp4b/miR-298-5p/Mef2c Regulates Cardiac Hypertrophy Induced by Angiotensin II

Xie,

Xu,

Xiong

et al. 2023

Int J Sports Med

View full text Add to dashboard Cite

Cardiac hypertrophy (CH) is an early marker in the clinical course of heart failure. Circular RNAs (circRNAs) play important roles in human disease. However, the role of circ_Larp4b in myocardial hypertrophy has not been studied. Angiotensin II (Ang II) treated HL-1 cells to induce a CH cell model. Quantitative real-time polymerase chain reaction was used to detect the expression of circ_Larp4b, microRNA-298-5p, and myocyte enhancer factor 2 (Mef2c). Western blot detected the protein level of alpha-actinin-2 (ACTN2), beta-myosin heavy chain (β-MHC), atrial natriuretic peptide (ANP), and Mef2c. The relationship between miR-298-5p and circ_Larp4b or Mef2c was verified by dual-luciferase reporter assay and RNA pull-down assay. Circ_Larp4b and Mef2c were upregulated in HL-1 cells treated with Ang II. Moreover, circ_Larp4b down-regulation regulated the progress of CH induced by Ang II. MiR-298-5p was a target of circ_Larp4b, and Mef2c was a target of miR-298-5p. Overexpressed Mef2c reversed the cell size inhibited by miR-298-5p in Ang II-induced HL-1 cells. Circ_Larp4b regulated CH progress by regulating miR-298-5p/Mef2c axis.

show abstract

Section: Discussionmentioning

confidence: 99%