miRNA‑135a regulates Hut78 cell proliferation via the GATA‑3/TOX signaling pathway

Wei, Hong; Liu, Ruifeng; Guo, Xvli; Zhou, Yin; Sun, Bo; Wang, Jialin

doi:10.3892/mmr.2019.9885

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Thus, we speculate that it is important to analyze the post-transcriptional regulation such as suppressive microRNA expression for understanding their molecular mechanisms ( Dinh et al, 2014 ; Melo et al, 2019 ; Bolandi et al, 2020 ). For example, the previous study reported that overexpression of miRNA-135a results in a significant decrease in the expression level of Gata3 protein, even though only minor changes in the Gata3 gene expression is observed ( Wei et al, 2019 ). Also, miRNA-27 and miRNA-128 indirectly regulate stabilities of Gata3 protein after transcription and affect lymphocyte differentiation ( Guerau-de-Arellano et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Carbon Black Nanoparticle on Neonatal Lymphoid Tissues Depending on the Gestational Period of Exposure in Mice

et al. 2021

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Introduction: Particulate air pollution, containing nanoparticles, enhances the risk of pediatric allergic diseases that is potentially associated with disruption of neonatal immune system. Previous studies have revealed that maternal exposure to carbon black nanoparticles (CB-NP) disturbs the development of the lymphoid tissues in newborns. Interestingly, the CB-NP-induced immune profiles were observed to be different depending on the gestational period of exposure. It is important to identify the critical exposure period to prevent toxic effects of nanoparticles on the development of the immune system. Therefore, the present study was aimed to investigate the effect of CB-NP on the development of neonatal lymphoid tissues in mice, depending on the gestational period of exposure.Methods: Pregnant ICR mice were treated with a suspension of CB-NP (95 μg/kg body weight) by intranasal instillation; the suspension was administered twice during each gestational period as follows: the pre-implantation period (gestational days 4 and 5), organogenesis period (gestational days 8 and 9), and fetal developmental period (gestational days 15 and 16). The spleen and thymus were collected from offspring mice at 1, 3, and 5-days post-partum. Splenocyte and thymocyte phenotypes were examined by flow cytometry. Gene expression in the spleen was examined by quantitative reverse transcription-polymerase chain reaction.Results: The numbers of total splenocytes and splenic CD3−B220− phenotype (non-T/non-B lymphocytes) in offspring on postnatal day 5 were significantly increased after exposure to CB-NP during the organogenesis period compared with other gestational periods of exposure and control (no exposure). In contrast, expression levels of mRNA associated with chemotaxis and differentiation of immune cells in the spleen were not affected by CB-NP exposure during any gestational period.Conclusion: The organogenesis period was the most susceptible period to CB-NP exposure with respect to lymphoid tissue development. Moreover, the findings of the present and previous studies suggested that long-term exposure to CB-NP across multiple gestational periods including the organogenesis period, rather than acute exposure only organogenesis period, may more severely affect the development of the immune system.

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Section: Discussionmentioning

confidence: 99%

Effect of Carbon Black Nanoparticle on Neonatal Lymphoid Tissues Depending on the Gestational Period of Exposure in Mice

et al. 2021

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“…It acts as an oncogene or tumor suppressor gene to regulate key processes such as tumor proliferation, differentiation, metastasis, apoptosis, and drug resistance. Wei et al 28 reported that miRNA-135a regulates Hut78 cell proliferation through the GATA3/TOX signaling pathway. In recent years, more and more people have realized that miRNA can be used as biomarkers to predict the prognosis and treatment response of various cancers.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of miR-421 predicts poor prognosis and promotes proliferation, migration, and invasion of papillary thyroid cancer cells

Dong

Zhang

Sun

et al. 2020

Journal of the Chinese Medical Association

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Background: Papillary thyroid carcinoma (PTC) represents the most frequent subtype of thyroid cancer (TC) with poor prognosis mainly due to the severe invasion and metastasis. As an oncogene, microRNA-421 (miR-421) is involved in the development of various cancers. This study was to investigate the clinical significance of miR-421 in PTC and its effects on the biological function of PTC cells. Methods: The expression level of miR-421 in all tissues and PTC cell lines was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Subsequently, the relationship between miR-421 expression and the clinicopathological feature was detected by chi-square analysis in 106 patients with PTC. In addition, Kaplan-Meier and multivariate Cox regression analysis were used to detect the survival time and the prognostic value of miR-421. Finally, the regulatory effect of miR-421 on the proliferation, migration, and invasion ability of PTC cells was detected by Cell Counting Kit (CCK-8) and Transwell assay. Results: Compared with all control groups, the expression of miR-421 was significantly increased in 106 patients tissues and PTC cell lines ( p < 0.001). In addition, patients with miR-421 upregulated in PTC showed more positive lymph node metastasis ( p = 0.011), positive tumor infiltration ( p = 0.031), and TNM stage III/IV ( p = 0.019), and when miR-421 expression level was elevated, the survival rate of PTC patients was poor (log-rank test, p = 0.023). Furthermore, miR-421 might be an independent prognostic biomarker for PTC (hazard ratio [HR] = 3.172, 95% CI = 1.071-9.393, p = 0.037). Finally, increased levels of miR-421 can significantly promote cell proliferation, migration, and invasion ( p < 0.01). Conclusion: miR-421 is a novel oncogene of PTC and is a valuable prognostic biomarker. Moreover, the upregulation of miR-421 enhances the proliferation, migration, and invasion of PTC cells.

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“…In addition, other miRs may play a role in CTCL, including miR-22, miR-135a and miR-223. Diminished expression of miR-135a, miR-223 and miR-22 may allow for the high expression of critical transcription factors including GATA3 as well as growth and proto-oncogenes such as E2F1 and c-Myc, respectively, collectively contributing to CTCL pathogenesis and progression [42,91,92].…”

Section: Key Tumor Suppressive Mirs Playing a Role In Ctcl Pathogenesismentioning

confidence: 99%

MicroRNAs in the Pathogenesis, Diagnosis, Prognosis and Targeted Treatment of Cutaneous T-Cell Lymphomas

Gluud

Willerslev-Olsen

Gjerdrum

et al. 2020

Cancers

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Cutaneous T-cell lymphoma (CTCL) represents a heterogeneous group of potentially devastating primary skin malignancies. Despite decades of intense research efforts, the pathogenesis is still not fully understood. In the early stages, both clinical and histopathological diagnosis is often difficult due to the ability of CTCL to masquerade as benign skin inflammatory dermatoses. Due to a lack of reliable biomarkers, it is also difficult to predict which patients will respond to therapy or progress towards severe recalcitrant disease. In this review, we discuss recent discoveries concerning dysregulated microRNA (miR) expression and putative pathological roles of oncogenic and tumor suppressive miRs in CTCL. We also focus on the interplay between miRs, histone deacetylase inhibitors, and oncogenic signaling pathways in malignant T cells as well as the impact of miRs in shaping the inflammatory tumor microenvironment. We highlight the potential use of miRs as diagnostic and prognostic markers, as well as their potential as therapeutic targets. Finally, we propose that the combined use of miR-modulating compounds with epigenetic drugs may provide a novel avenue for boosting the clinical efficacy of existing anti-cancer therapies in CTCL.

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miRNA‑135a regulates Hut78 cell proliferation via the GATA‑3/TOX signaling pathway

Cited by 4 publications

References 35 publications

Effect of Carbon Black Nanoparticle on Neonatal Lymphoid Tissues Depending on the Gestational Period of Exposure in Mice

Effect of Carbon Black Nanoparticle on Neonatal Lymphoid Tissues Depending on the Gestational Period of Exposure in Mice

Upregulation of miR-421 predicts poor prognosis and promotes proliferation, migration, and invasion of papillary thyroid cancer cells

MicroRNAs in the Pathogenesis, Diagnosis, Prognosis and Targeted Treatment of Cutaneous T-Cell Lymphomas

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