miRandola: Extracellular Circulating MicroRNAs Database

Russo, Francesco; Bella, Sebastiano Di; Nigita, Giovanni; Macca, Valentina; Laganà, Alessandro; Giugno, Rosalba; Pulvirenti, Alfredo; Ferro, Alfredo

doi:10.1371/journal.pone.0047786

Cited by 155 publications

(113 citation statements)

References 32 publications

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“…The expression of let-7a was significantly reduced in severe asthma compared to mild asthma and controls, whereas the expressions of miR-21 and miR-223 were not altered. Altered expression of let-7a has been found in many diseases; for example, in various cancers, Alzheimer's disease, and immune system diseases, such as asthma, allergies, allergic rhinitis, and atopic dermatitis 37 . Let-7a is highly expressed in human lungs 19 and it is hypothesized to have an anti-inflammatory role 38 .…”

Section: Discussionmentioning

confidence: 99%

Let-7a is differentially expressed in bronchial biopsies of patients with severe asthma

Rijavec

Korošec

Žavbi

et al. 2014

Sci Rep

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Asthma is a chronic inflammatory disease. Around 5 to 10% of patients classified as having severe asthma can-not be adequately controlled despite the use of all currently available therapeutic approaches. Previous studies have revealed the potential important role of miRNAs in the regulation of a variety of inflammatory processes, including asthma. Expression of selected miRNAs, specifically let-7a, miR-21 and miR-223, that were shown to have important roles in asthma pathogenesis, were analyzed in bronchial biopsies of 24 patients with asthma, 12 mild and 12 severe and 10 controls with no chronic disease. We found significantly reduced expression of let-7a in bronchial biopsies from patients with severe asthma in comparison to patients with mild asthma as well as in comparison to the non-asthmatic controls. On the other hand, no significant differences in miR-21 and miR-223 expression were found between the different groups analyzed. Reduced let-7a levels in bronchial biopsies of patients with severe therapy-resistant asthma could not only be used as a potential biomarker to discriminate between different asthma phenotypes, but also might be a target for modulation of treatment at the inflammatory site for a group of patients that are most affected and still lack effective treatment.

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Section: Discussionmentioning

confidence: 99%

Let-7a is differentially expressed in bronchial biopsies of patients with severe asthma

Rijavec

Korošec

Žavbi

et al. 2014

Sci Rep

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show abstract

“…This nomenclature has been replaced with -5p/-3p in miRBase. The miRandola database (http://atlas.dmi.unict.it/mirandola/tools.php; Russo et al 2012) identified the most current name for each miRNA included in our Affymetrix array that did not have an updated nomenclature. miRNA, microRNA.…”

Section: Validation Of Microarray Mirna Expression Profiles By Qrt-pcrmentioning

confidence: 99%

Upregulation of Gingival Tissue miR-200b in Obese Periodontitis Subjects

et al. 2015

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“…In addition, a database called miRandola has been designed to catalog all extracellular circulating microRNAs and at present contains 2312 entries with 581 unique mature microRNAs observed in circulation from 21 different types of samples [103].…”

Section: Techniques For Isolation and Identification Of Exosomesmentioning

confidence: 99%