Mirages Francais-French Literature in German Eyes

Hypersensitivity Fever

“…Rabbits deliberately infected with the Giorgio strain showed enhanced responses from filtrates of this organism. For these and other reasons it was postulated that fever from staphylococcal filtrates was a delayed hypersensitivity reaction in animals who had acquired a natural infection (Atkins 1963a, 1963b; Atkins & Freedman 1963). Culture filtrates of the 80‐81 strain of Staphylococcus aureus were normally non‐pyrogenic to rabbits but febrile responses to this material appeared several weeks after induced infection with live organisms of this strain.…”

“…However in vitro activation of this type has now been demonstrated for macrophage cells (monocytes) obtained from lung washings of the rabbit immunised with BCG which cells when incubated with tuberculin yield considerable quantities of EP (Atkins et al 1967;Hahn et al 1967). This very brief summary of the general pathology of fever serves to introduce the two special aspects -hypersensitivity and clinical considerations -which are the purpose of this paper, but further reading on the subject is given in Atkins &1968).…”