Miracles do happen: meeting the challenges of providing rare blood through the American Rare Donor Program

Flickinger, Cynthia

doi:10.21307/immunohematology-2019-049

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…11,12,13,14 In this study, the presence of the RHCE*Cde/cde (r'r), *Cde/cdE (r'r"), *cDe/cDe(Ro), KEL*K (k-), KEL*KPA (Kpb-) and LU*A (Lub-) in White South Africans matched the findings in Caucasian populations of Italy, Netherlands, America, Spain, Germany and Austria. 15,16,17,18,19 Further, the rare E-Hrb-and E-HrSfound among Black South Africans matched findings in the African American population. 20,21,22 The JS*A,JS*A genotype (Jsb-) was found in three Black South Africans and one Indian donor which is not common in South Africa.…”

Section: Discussionsupporting

confidence: 53%

“…The genotype GYPB*S, GYPB*S or s-phenotype is currently not listed as a rare type in South Africa as it is not difficult to locate; however, s-is listed on the rare donor files of Spain 18 and Japan. 23 Although the S-s-U-phenotype predicted by the GYPB*deletion is rare in Caucasians and found mainly in African Americans, 17 it was found in one White and one Black donor in the present study. This suggests the presence of this rare blood type among White South Africans.…”

Section: Discussioncontrasting

confidence: 52%

“…The n of the Yta(Yta-) can be attributed to the small study size or area of India sampled. The Yta-antigen was also identified in Italy, 15 America, 17 Spain, 18 Japan 23 and Canada 25 prompting a decision to expand screening for this rare antigen in South Africa to all race groups.…”

Section: Discussionmentioning

confidence: 99%

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Molecular red cell genotyping of rare blood donors in South Africa to enhance rare donor-patient blood matching

et al. 2021

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Background: Molecular red cell genotyping is devoid of serology limitations such as the scarcity of rare antisera and the possibility of inconclusive results due to biological interferences. Blood incompatibility can result in immune transfusion reactions such as haemolytic transfusion reactions or haemolytic disease of the foetus and newborn.Objective: The study aimed to use molecular red cell genotyping to identify rare blood group donors among South African blood donors.Methods: Red cell genotyping data were extracted retrospectively from the BIDS XT genotyping software in the Immunohaematology Reference Laboratory from January 2015 to August 2016. The ID CORE XT genotyping assay was used to identify the single nucleotide polymorphisms of 10 blood groups system alleles in 150 donors. Associations between the resultant genotypes and predicted phenotypes, ABO group, RhD type, race group and gender were studied.Results: Significant red cell genetic variability was noted among the numerous South African donor genotypes identified in this study. Genotyping further confirmed the presence of at least one of the 16 rare genotypes in 50 donors. Group O Black donors were associated with two rare blood types, while several other rare blood types were found only in White donors, supporting an association between ABO/Rh subtype, race group and rare blood types.Conclusion: Targeted screening of donors for antigen-negative rare blood units for patients should be done to reduce the risk of haemolytic transfusion reactions and haemolytic disease of the foetus and newborn.

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Section: Discussionsupporting

confidence: 53%

Section: Discussioncontrasting

confidence: 52%

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Molecular red cell genotyping of rare blood donors in South Africa to enhance rare donor-patient blood matching

et al. 2021

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Red cell genotyping of rare blood donors: donation behaviour and data visualization

2021

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Background The continual identification of rare blood among donors is critical to support national programs like the American Rare Donor Program (ARDP). Some blood centres require consent from donors to be registered with a national registry. This situation provides an opportunity to determine whether a donor's willingness to register is associated with a change in donation behaviour.Methods Rare donors were identified by molecular typing. The average number of donations per year was compared for each donor prior to and after receiving a consent letter. Donors were categorized as either accepting or declining the request. Non-parametric t tests compared the statistical significance within and between categories. Rare types were overlaid with consensus data to look for trends using data visualization techniques.Results A total of 270 molecularly typed rare donors received letters over 4 years. Half of the donors (132, 49%) agreed to participate in the ARDP. Overall, donation frequency increased after the letter when enrolled. Both Caucasian and non-Caucasian donors increased their donations after enrolling providing an additional 159 red blood cell units over 3 years. Declining participation did not change donation frequency. Data visualization showed that enrolled donors were more affluent, high school and college educated, and lived in their home for longer periods of time.Conclusion A donor's willingness to enrol in the ARDP was associated with a post-response increase in donation frequency. New interventions to reach non-Caucasian donors may be a prerequisite to increase donation frequency and a willingness to be a rare blood donor.

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Miracles do happen: meeting the challenges of providing rare blood through the American Rare Donor Program

Cited by 2 publications

References 2 publications

Molecular red cell genotyping of rare blood donors in South Africa to enhance rare donor-patient blood matching

Molecular red cell genotyping of rare blood donors in South Africa to enhance rare donor-patient blood matching

Red cell genotyping of rare blood donors: donation behaviour and data visualization

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