Abstract:Background
Metastasis leads to recurrence and death in colorectal cancer (CRC) patients; however, mechanisms underlying CRC metastasis, especially in its initial stages, remain largely unknown. In this study, we aim to identify long noncoding RNAs (lncRNAs) functionally involved in CRC metastasis initiation and their regulation that could lead to targeted therapeutics.
Methods
We performed whole transcriptome sequencing using CRC cell lines with divergent spontaneous metastatic properties. The biological rol… Show more
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