Abstract:This study was designed to explore the role of MiR203 promoter methylation in the process of Barrett's esophagus carcinogenesis. RT-PCR was used to detect the expression levels of miRNA-203 in Barrett's esophagus, esophageal cancer and normal esophageal mucosa cell lines, before and after the treatment of demethylation. MiR203 promoter methylation levels in these cell lines were measured by Methylation Specific PCR (MSP). Immunohistochemistry was used to test the expression and distribution of K-Ras, a target … Show more
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