MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2β

Qiu, Feng; Simei, He; Zhang, Zilong; Dai, Siyu; Wang, J.; Liu, Ning; Li, Zhiwei; Hu, Xiang; Xiang, Sheng; Wei, Chenxi

doi:10.1016/j.fct.2023.113888

Cited by 2 publications

(4 citation statements)

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“…6−10 Our previous study demonstrated that oral exposure to DEHP led to learning and memory impairment, as well as damage to mouse hippocampus. 27 We found that the learning and memory impairment caused by DEHP was relieved by C. butyricum treatment in the MWM test. During the hidden platform experiment period, the mice in the C. butyricum treatment group had significantly (p < 0.05) shorter escape latency than the mice in the DEHP exposure group (Figure 1B).…”

Section: Butyricum Relieved Learning and Memorymentioning

confidence: 71%

“…Studies have indicated the negative effect of DEHP on neural development, behavior, and cognition. − Our previous study demonstrated that oral exposure to DEHP led to learning and memory impairment, as well as damage to mouse hippocampus …”

Section: Resultsmentioning

confidence: 99%

“…butyricum treatment group were both fed diluted DEHP solution at a dose of 5 mg/kg BW every day. This dose of DEHP was chosen based on our previous study, which has been confirmed to induce learning and memory impairment in mice . In addition, the mice in the C.…”

Section: Methodsmentioning

confidence: 99%

“…This dose of DEHP was chosen based on our previous study, which has been confirmed to induce learning and memory impairment in mice. 27 In addition, the mice in the C. butyricum treatment group were fed C. butyricum diluted with sterile normal saline at a dose of 1 × 10 8 CFU/kg BW by gavage every 2 days.…”

Section: 2mentioning

confidence: 99%

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Clostridium butyricum Alleviates DEHP Plasticizer-Induced Learning and Memory Impairment in Mice via Gut–Brain Axis

Wang,

Qiu,

Zhang

et al. 2023

J. Agric. Food Chem.

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phthalate (DEHP) plasticizer, a well-known environmental and food pollutant, has neurotoxicity. However, it is unknown whether DEHP leads to learning and memory impairment through gut−brain axis and whether Clostridium butyricum can alleviate this impairment. Here, C57BL/6 mice were exposed to DEHP and treated with C. butyricum. Learning and memory abilities were evaluated through the Morris water maze. The levels of synaptic proteins, inflammatory cytokines, and 5hydroxytryptamine (5-HT) were detected by immunohistochemistry or ELISA. Gut microbiota were analyzed through 16S rRNA sequencing. C. butyricum alleviated DEHP-induced learning and memory impairment and restored synaptic proteins. It significantly relieved DEHP-induced inflammation and recovered 5-HT levels. C. butyricum recovered the richness of the gut microbiota decreased by DEHP, with the Bif idobacterium genus increasing the most. Overall, C. butyricum alleviated DEHP-induced learning and memory impairment due to reduced inflammation and increased 5-HT secretion, which was partly attributed to the recovery of gut microbiota.

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Section: Butyricum Relieved Learning and Memorymentioning

confidence: 71%