MiR-92a promotes stem cell-like properties by activating Wnt/β-catenin signaling in colorectal cancer

Zhang, Guangjun; Li, Lifa; Yang, Guodong; Xia, Shu-Sen; Wang, Rong; Leng, Zhengwei; Liu, Zuo-Liang; Tian, Hongpeng; He, Yi; Meng, Chunyan; Liu, Daizhi; Hou, Songlin; Tang, Xuegui; Zhou, Tong

doi:10.18632/oncotarget.21667

Cited by 44 publications

(31 citation statements)

References 47 publications

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“…(also called gut-enriched Krüppel-like factor or GKL) 24 A number of miRNAs can bind to the 3′-untranslated region (3′-UTR) of KLF4 mRNA. [25][26][27][30][31][32][33][34] Hence, we predicted 15…”

Section: Discussionmentioning

confidence: 86%

“…It is now well established that KLF4 (also called gut‐enriched Krüppel‐like factor or GKL) is a key suppressor gene in CRC involved in multiple key CRC pathways such as Notch pathway and Wnt/β‐catenin pathway . A number of miRNAs can bind to the 3′‐untranslated region (3′‐UTR) of KLF4 mRNA . Hence, we predicted 15 candidate circRNAs as KLF4 ceRNA in CRC tissues (Figure ).…”

Section: Discussionmentioning

confidence: 99%

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Expression profiles of circular RNAs in human colorectal cancer based on RNA deep sequencing

Jin

et al. 2019

Clinical Laboratory Analysis

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BackgroundCircular RNAs (circRNAs) are a novel group of RNAs and play essential roles in cancers. However, the expression profiles of circRNAs in human colorectal cancer (CRC) are largely unclear.MethodsThe differentially expressed circRNAs, mRNAs, and microRNAs (miRNAs) between CRC tissues and paired adjacent normal tissues were first screened. Then, gene ontology and pathway analyses were performed to predict the possible functions. In addition, we identified the differentially expressed circRNAs in CRC correlated with Krüppel‐like factor 4 (KLF4) and validated their expression levels in CRC tissues. Finally, the correlations between hsa_circ_0142527 expression levels and clinicopathological features of patients with CRC were also analyzed.ResultsAfter filtered 4735 circRNAs by RNA deep sequencing, 67 differentially expressed circRNAs (fold change >2.0, P < 0.05) were selected. The top two pathways were cell cycle and other glycan degradation. Hsa_circ_0142527 and KLF4 mRNA were significantly lower expressed in CRC tissues in both training and confirm groups and have high positive correlation (r = 0.754). We further found that the expression levels of hsa_circ_0142527 were significantly associated with age (P = 0.004), differentiation (P = 0.008), invasion (P = 0.029), distal metastasis (P = 0.004), TNM stage (P = 0.005), and carcinoembryonic antigen (CEA; P = 0.037).ConclusionsThe circRNA expression profile of CRC provided new clues for understanding the occurrence of CRC. Hsa_circ_0142527 may be served as a potential biomarker for the diagnosis of CRC.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Expression profiles of circular RNAs in human colorectal cancer based on RNA deep sequencing

Jin

et al. 2019

Clinical Laboratory Analysis

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“…In the studies of colorectal cancer, hepatocellular carcinoma, pancreatic cancer, cervical cancer and osteosarcoma, miR-92a was reported to exert oncogenic influence on cancer progression. [9][10][11][12][13][14] However, our data revealed a tumor suppressive role of miR-92a in PCa using both gain-and loss-of function assays. These indicate that the functional influence of miR-92a in human cancers differs in different types of human cancers.…”

Section: Discussionmentioning

confidence: 98%

MicroRNA-92a Inhibits the Cell Viability and Metastasis of Prostate Cancer by Targeting SOX4

Liao

Xiong

Tang

et al. 2020

Technol Cancer Res Treat

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MicroRNAs (miRNAs) was confirmed to play an active role in the pathogenesis of prostate cancer (PCa). The expression and biological function for miR-92a in PCa remains unknown. In this study, we demonstrated that miR-92a expression was decreased in PCa tissues and cells lines. Overexpression miR-92a inhibited the cell viability, migration and invasion of PC-3 while inhibition of miR-92a led to opposite alteration of cell viability and metastasis of DU-145 cells. Mechanically, we confirmed that miR-92a interacted with 3’-UTR of SOX4 through the complementary sequences by luciferase reporter assay. qRT-PCR and western blot confirmed that miR-92a inhibited the expression of SOX4 in PCa cells. Moreover, overexpression of SOX4 reversed the inhibitory effects of miR-92a overexpression on PC-3 cell viability, migration and invasion, while knockdown of SOX4 suppressed the promoting effects of miR-92a knockdown on these biological functions of DU-145 cells. Therefore, our study indicates that miR-92a inhibits the growth and metastasis of prostate cancer by targeting SOX4, and can potentially serve as a biomarker and treatment target for PCa patients.

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“…As a result, podocyte exhibits cell cycle arrest mediated by p57kip2 regulation after inhibiting miR-92a. It is noticed that GSK3β appears to act as a direct target of miR-92a and triggers downstream β-catenin activation [186,187]. Furthermore, attenuated GSK3 results in the expression of Ajuba and accordingly nucleus YAP/TAZ accumulation contributes cell cycle re-entry and mitotic catastrophe [188] (Fig.…”

Section: Gsk3β In Podocyte Cell Re-entrymentioning

confidence: 96%

GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm

Liu

Chiang

Kao

et al. 2020

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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MiR-92a promotes stem cell-like properties by activating Wnt/β-catenin signaling in colorectal cancer

Cited by 44 publications

References 47 publications

Expression profiles of circular RNAs in human colorectal cancer based on RNA deep sequencing

Expression profiles of circular RNAs in human colorectal cancer based on RNA deep sequencing

MicroRNA-92a Inhibits the Cell Viability and Metastasis of Prostate Cancer by Targeting SOX4

GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm

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