miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer

Shayimu, Paerhati; Wang, Jingbin; Liu, Lin; Tuerdi, Rousidan; Yu, Caiyan; Yusufu, Aikeremu

doi:10.1002/kjm2.12155

Cited by 8 publications

(7 citation statements)

References 21 publications

(31 reference statements)

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“…Secondly, it may be involved in ubiquitination and subsequent proteasomal degradation as a substrate-recognition module via the recruitment of E3 ubiquitin ligases complex [36,37]. Previous studies demonstrated that SOCS1 was low expression in many types of cancer, such as anaplastic thyroid cancer [38], gastric cancer [39], hypopharyngeal carcinoma [40], and breast cancer [41]. however, several studies have also shown that SOCS1 expression level was increased in colorectal cancer [42], glioblastoma [43], and triple-negative breast cancer [44].…”

Section: Discussionmentioning

confidence: 99%

Expression Status and Prognostic Values of SOCS Family Genes in Non-small Cell Lung Cancer

Zhang¹,

Sun²,

Bao³

2021

Preprint

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Backgroud:Suppressors of cytokine signaling (SOCS) family play important roles in the development of cancers by inhibiting the transmission of the Janus kinases–signal transducers and activators of transcription (JAK-STAT) signaling pathway. However, the expression patterns and prognostic value of SOCS family genes in non-small cell lung cancer (NSCLC) remains unclear. Methods: The SOCS family genes expression profiles were explored using ONCOMINE and GEPIA online tools. The mutation and copy number alterations of SOCS family genes in NSCLC were assessed by cBioportal for Cancer Genomics. The methylation status of SOCS family members were analyzed through MEXPRESS and UCSC Xena website. The prognostic values of SOCS family genes in NSCLC were explored through Kaplan-Meier Plotter database. Results: The expression levels of SOCS2, SOCS3, and cytokine-inducible SH2-containing protein (CIS/CISH) were significantly reduced in NSCLC tissues compared to normal lung tissues. The aberrant DNA methylation of SOCS family genes were frequent in NSCLC. CISH methylation was negatively correlated with gene expression in NSCLC. The Kaplan-Meier Plotter analysis demonstrated high expression of SOCS1 may be a predictor of poor prognosis in lung adenocarcinoma(LUAD) but served as a favorable prognostic marker of lung squamous cell carcinoma. The high expression levels of SOCS2 and SOCS4-7 were significantly correlated with better overall survival (OS) in LUAD but not in lung squamous carcinoma (LUSC) patients. Conclusions:Our findings indicated that the aberrant gene expression and DNA methylation of SOCS family members are common in NSCLC and contribute to tumorigenesis. SOCS family genes may serve as therapeutic targets and prognostic biomarkers for NSCLC patients

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Section: Discussionmentioning

confidence: 99%

Expression Status and Prognostic Values of SOCS Family Genes in Non-small Cell Lung Cancer

Zhang¹,

Sun²,

Bao³

2021

Preprint

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“…miRNAs control expression of their target mRNAs principally by binding to the 3'-untranslated region (3'-UTR) to inhibit the translation of mRNA and decrease its half-life. miR-922 is a tumor-promoting gene that promotes the development and progression of tumors (6,7). miR-922 expression levels are decreased in breast cancer (8).…”

Section: Introductionmentioning

confidence: 99%

CREB1 acts via the miR‑922/ARID2 axis to enhance malignant behavior of liver cancer cells

et al. 2021

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There is little information on the role of microRNA (miR)-922 in the malignant behavior of liver cancer. The present study investigated the regulation of miR-922 expression levels by cAMP response element binding protein 1 (CREB1) in liver cancer tissue, its role in regulating malignant behavior and its potential targets in liver cancer. miR-922 expression in liver cancer cells and tissue was determined by reverse transcription-quantitative PCR. The binding of CREB1 to the promoter region of mir-922 was tested by chromatin immunoprecipitation-PCR. The predicted AT-rich interactive domain 2 (ARID2) and fidgetin, microtubule severing factor targets of miR-922 were characterized by dual luciferase reporter assay. The effects of altered ARID2 expression levels on miR-922-enhanced malignant behavior of liver cancer cells were tested. CREB1 bound to the promoter region of miR-922. Elevated miR-922 transcripts were inversely associated with ARID2 expression in liver cancer tissue and cells. miR-922 inhibited ARID2-regulated luciferase expression and was present in the miR/argonaute RISC catalytic component 2 complex. ARID2 significantly decreased malignant behavior of liver cancer MHCC97L cells. Similarly, ARID2 over-expression inhibited growth of xenograft liver cancer tumors and decreased miR-922, Bcl-2, proliferating cell nuclear antigen, cyclin D1, MMP3 and MMP9 expression and serum VEGF and TNF-α levels, but enhanced Bax expression levels in tumors. ARID2 over-expression abrogated malignant behavior promoted by miR-922 over-expression and enhanced miR-922-decreased malignant behavior of liver cancer cells. CREB induced miR-922 transcription, which targeted ARID2 to enhance malignant behavior of liver cancer cells, indicating that the CREB1/miR-922/ARID2 axis may be a potential target for liver cancer treatment.

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“…miR-922, which has been found to be overexpressed in GC, targets the SOCS1 gene and negatively regulates its expression by activating the JAK and AKT pathways, promoting tumor cell proliferation and motility. Conversely, downregulation of miR-922 increases SOCS1 expression and promotes the apoptosis of GC cells ( 52 ).…”

Section: Epigenetic Modulations Of Cytokines In Gcmentioning

confidence: 99%

Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance

Reyes,

Pulgar,

Vivallo

et al. 2024

Front. Immunol.

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Cytokines are proteins that act in the immune response and inflammation and have been associated with the development of some types of cancer, such as gastric cancer (GC). GC is a malignant neoplasm that ranks fifth in incidence and third in cancer-related mortality worldwide, making it a major public health issue. Recent studies have focused on the role these cytokines may play in GC associated with angiogenesis, metastasis, and chemoresistance, which are key factors that can affect carcinogenesis and tumor progression, quality, and patient survival. These inflammatory mediators can be regulated by epigenetic modifications such as DNA methylation, histone protein modification, and non-coding RNA, which results in the silencing or overexpression of key genes in GC, presenting different targets of action, either direct or mediated by modifications in key genes of cytokine-related signaling pathways. This review seeks insight into the relationship between cytokine-associated epigenetic regulation and its potential effects on the different stages of development and chemoresistance in GC.

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miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer

Cited by 8 publications

References 21 publications

Expression Status and Prognostic Values of SOCS Family Genes in Non-small Cell Lung Cancer

Expression Status and Prognostic Values of SOCS Family Genes in Non-small Cell Lung Cancer

CREB1 acts via the miR‑922/ARID2 axis to enhance malignant behavior of liver cancer cells

Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance

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