miR-874: An Important Regulator in Human Diseases

Zhang, Qiudan; Zhong, Chenming; Yan, Qiliang; Zeng, Linghui; Gao, Wei; Duan, Shiwei

doi:10.3389/fcell.2022.784968

Cited by 5 publications

(5 citation statements)

References 73 publications

(155 reference statements)

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“…By examining the ceRNA regulation network in CRC, we identified 3 core miRNAs (i.e., mir-874, mir-92a-1, and mir-940) in this study. MiR-874 has been shown to be downregulated in 22 tumors and abnormally expressed in 18 diseases other than cancer ( 20 ). MiR-874 malfunction is not only associated with the diagnosis and prognosis of tumor patients, but also has a significant effect on the efficacy of chemotherapy and radiotherapy ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of key modules and micro RNAs associated with colorectal cancer via a weighted gene co-expression network analysis and competing endogenous RNA network analysis

Li¹,

Ruan²,

Ma³

et al. 2023

J Gastrointest Oncol

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Background Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide, and the incidence of CRC has increased rapidly in recent years. Due to the high invasiveness of colonoscopy and the low accuracy of alternative diagnostic methods, the diagnosis of CRC remains a serious problem. Thus, molecular biomarkers for CRC need to be identified. Methods In this study, RNA-sequencing data from The Cancer Genome Atlas (TCGA) database were used to identify the long non-coding RNAs (lncRNAs), messenger RNAs (mRNAs), and micro RNAs (miRNAs) that were differentially expressed between the CRC and normal tissues. Based on the gene expression and clinical features, the results of the weighted gene co-expression network analysis (WGCNA) and the binding relationships between miRNAs and lncRNAs and mRNAs were used to establish a CRC-related competing endogenous RNA (ceRNA) network. Results The core miRNAs (i.e., mir-874, mir-92a-1, and mir-940) in the network were identified. Among them, mir-874 was negatively correlated with the overall survival (OS) of patients. The protein-coding genes in the ceRNA network included IZUMO4 , WT1 , NPEPL1 , TEX22 , PPFIA4 , and SFXN3 , and the lncRNAs were LINC00858 and PRR7-AS1 . These genes were significantly highly expressed in CRC according to validations in other independent data sets. Conclusions In conclusion, this study established a network of the co-expressed ceRNAs associated with CRC and identified the genes and miRNAs related to the prognosis of CRC patients.

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Section: Discussionmentioning

confidence: 99%

Identification of key modules and micro RNAs associated with colorectal cancer via a weighted gene co-expression network analysis and competing endogenous RNA network analysis

Li¹,

Ruan²,

Ma³

et al. 2023

J Gastrointest Oncol

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“…miR-874 is a novel anti-cancer miRNA. Through the inhibition of gene expression, miR-874 retains a key role in numerous cellular mechanisms, including but not limited to apoptosis, cell proliferation, and migration [ 55 ]. Interestingly, in sepsis-induced ARDS, lncRNA H19 was shown to have great value as an early diagnostic tool.…”

Section: Aquaporin Long Non-coding Rnas and Micro Rnas In Clinical An...mentioning

confidence: 99%

Aquaporin Expression and Regulation in Clinical and Experimental Sepsis

Lotsios,

Keskinidou,

Dimopoulou

et al. 2023

IJMS

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Sepsis is an inflammatory disorder caused by the host’s dysfunctional response to infection. Septic patients present diverse clinical characteristics, and in the recent years, it has been the main cause of death in intensive care units (ICU). Aquaporins, membrane proteins with a role in water transportation, have been reported to participate in numerous biological processes. Their role in sepsis progression has been studied extensively. This review aims to examine recent literature on aquaporin expression and regulation in clinical sepsis, as well as established experimental models of sepsis. We will present how sepsis affects aquaporin expression at the molecular and protein level. Moreover, we will delve into the importance of aquaporin regulation at transcriptional, post-transcriptional, translational, and post-translational levels in sepsis by presenting data on aquaporin regulation by non-coding RNAs and selected chemical molecules. Finally, we will focus on the importance of aquaporin single-nucleotide polymorphisms in the setting of sepsis.

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“…Given this, mechanisms of HDAC1 inhibition became prominently sought. Although miR-449 and miR-874 have been shown to target HDAC1 in various cancer types, their implication in the enzyme's regulation in GBM has not been widely explored yet [83][84][85][86][87].…”

Section: Regulation Of Histone Acetyltransferases and Deacetylases By...mentioning

confidence: 99%

The Role of Non-Coding RNAs in Epigenetic Dysregulation in Glioblastoma Development

Isachesku,

Braicu,

Pirlog

et al. 2023

IJMS

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Glioblastoma (GBM) is a primary brain tumor arising from glial cells. The tumor is highly aggressive, the reason for which it has become the deadliest brain tumor type with the poorest prognosis. Like other cancers, it compromises molecular alteration on genetic and epigenetic levels. Epigenetics refers to changes in gene expression or cellular phenotype without the occurrence of any genetic mutations or DNA sequence alterations in the driver tumor-related genes. These epigenetic changes are reversible, making them convenient targets in cancer therapy. Therefore, we aim to review critical epigenetic dysregulation processes in glioblastoma. We will highlight the significant affected tumor-related pathways and their outcomes, such as regulation of cell cycle progression, cell growth, apoptosis, angiogenesis, cell invasiveness, immune evasion, or acquirement of drug resistance. Examples of molecular changes induced by epigenetic modifications, such as DNA epigenetic alterations, histone post-translational modifications (PTMs), and non-coding RNA (ncRNA) regulation, are highlighted. As understanding the role of epigenetic regulators and underlying molecular mechanisms in the overall pro-tumorigenic landscape of glioblastoma is essential, this literature study will provide valuable insights for establishing the prognostic or diagnostic value of various non-coding transcripts, including miRNAs.

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miR-874: An Important Regulator in Human Diseases

Cited by 5 publications

References 73 publications

Identification of key modules and micro RNAs associated with colorectal cancer via a weighted gene co-expression network analysis and competing endogenous RNA network analysis

Identification of key modules and micro RNAs associated with colorectal cancer via a weighted gene co-expression network analysis and competing endogenous RNA network analysis

Aquaporin Expression and Regulation in Clinical and Experimental Sepsis

The Role of Non-Coding RNAs in Epigenetic Dysregulation in Glioblastoma Development

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