MiR-770-5p, miR-661 and miR-571 expression level in serum and tissue samples of foot ulcer caused by diabetes mellitus type II in Iranian population

VatanIman, Rashin; Malekpour, Seyed Hossein; Afshari, Afsoon; Zare, Maryam

doi:10.1007/s11033-021-06798-9

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…MiR-571 was upregulated by hypoglycemia and, together with miR-1303, it has been associated with T2D, particularly in patients with complications ( 42 ), most particularly microvascular complications ( 50 ). Similarly, miR-661 was upregulated and, together with miR-1303 and miR-571, it has been related to the development of microvascular complications ( 50 ), including nephropathy ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

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MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes

et al. 2022

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ObjectiveHypoglycemia in type 2 diabetes (T2D) increases morbidity and mortality but the underlying physiological response is still not fully understood, though physiological changes are still apparent 24 hours after the event. Small noncoding microRNA (miRNA) have multiple downstream biological effects that may respond rapidly to stress. We hypothesized that hypoglycemia would induce rapid miRNA changes; therefore, this pilot exploratory study was undertaken.MethodsA pilot prospective, parallel study in T2D (n=23) and controls (n=23). Insulin-induced hypoglycemia (2mmol/l: 36mg/dl) was induced and blood sampling performed at baseline and hypoglycemia. Initial profiling of miRNA was undertaken on pooled samples identified 96 miRNA that were differentially regulated, followed by validation on a custom designed 112 miRNA panel.ResultsNine miRNAs differed from baseline to hypoglycemia in control subjects; eight were upregulated: miR-1303, miR-let-7e-5p, miR-1267, miR-30a-5p, miR-571, miR-661, miR-770-5p, miR-892b and one was downregulated: miR-652-3p. None of the miRNAs differed from baseline in T2D subjects.ConclusionA rapid miRNA response reflecting protective pathways was seen in control subjects that appeared to be lost in T2D, suggesting that mitigating responses to hypoglycemia with blunting of the counter-regulatory response in T2D occurs even in patients with short duration of disease.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT03102801?term=NCT03102801&draw=2&rank=1, identifier NCT03102801.

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Section: Discussionmentioning

confidence: 99%

“…MiR-770-5p was upregulated in low glucose and its expression has been associated with podocyte inflammation and apoptosis ( 51 , 52 ) and, together with miR-661 and miR-571, it was associated with diabetes microvascular complications ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes

et al. 2022

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The important role of miR-770 as a novel potential diagnostic and therapeutic target for human cancer and other diseases

Khalilian

Imani

Hosseini

et al. 2023

Pathology - Research and Practice

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Molecular mechanism and intervention measures of microvascular complications in diabetes

Xu,

Fang,

Wang

et al. 2024

Open Medicine

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Objective In this article, the epidemiology, molecular mechanism of occurrence and development, risk factors, and treatment of diabetic microvascular complications such as diabetic nephropathy, diabetic retinopathy, and diabetic peripheral neuropathy were discussed, providing the theoretical basis for more accurate elucidation of the pathogenesis and treatment of diabetic microvascular complications. Methods The electronic database of PubMed was searched, and retrieved papers were screened for eligibility by two independent reviewers. Data were extracted using a standardized data extraction form and the quality of included papers was assessed. Results Thirty-eight articles were included. Diabetes nephropathy, diabetes peripheral neuropathy, and diabetes retinopathy are the most common and serious microvascular complications of diabetes in clinical patients. Renin–angiotensin system blockers, beta drugs, statins, antivascular endothelial growth factor drugs, and antioxidants can inhibit the occurrence of microvascular complications in diabetes. Conclusions However, there has been no breakthrough in the treatment of diabetic microvascular complications. Therefore, prevention of diabetic microvascular complications is more important than treatment.

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MiR-770-5p, miR-661 and miR-571 expression level in serum and tissue samples of foot ulcer caused by diabetes mellitus type II in Iranian population

Cited by 3 publications

References 40 publications

MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes

MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes

The important role of miR-770 as a novel potential diagnostic and therapeutic target for human cancer and other diseases

Molecular mechanism and intervention measures of microvascular complications in diabetes

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