MiR-703 protects against hypoxia/reoxygenation-induced cardiomyocyte injury via inhibiting the NLRP3/caspase-1-mediated pyroptosis

Wei, Xiaoliang; Hu, Peng; Deng, Ming; Feng, Zhen; Peng, Changnong; Yang, Dahao

doi:10.1007/s10863-020-09832-w

Cited by 18 publications

(36 citation statements)

References 22 publications

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“…Programmed necrosis mainly contains necroptosis, mitochondrial permeability transition‐associated necrosis, ferroptosis and pyroptosis 7,35,36 . Currently, myocardial pyroptosis is considered to be one of the pivotal pathogenetic mechanisms of MIRI and has drawn considerable attentions during MIRI 6,7,10,11,36 . Pyroptosis acts as a pro‐inflammatory cell death and was characterized as NLRP3‐caspase‐1‐dependent response 6,7,10,11,36 .…”

Section: Discussionmentioning

confidence: 99%

“…MIRI affects clinical efficacy of revascularization strategies and serves as an important factor in worsening heart structure and function 1‐3,6,7 . Although programmed cell death that mainly contains necrosis, apoptosis and autophagy acts as the major pathogenesis in the development of MIRI, 3,8,9 it is now verified that pyroptosis‐associated necrosis also plays important roles in MIRI 6,7,10 …”

Section: Introductionmentioning

confidence: 99%

“…Pyroptosis acts as a pro‐inflammatory programmed cell death and was characterized as a NLRP3‐caspase‐1‐dependent response during MIRI 6,7,10,11 . When NLRP3 is stimulated, the inactive pro‐caspase‐1 is hydrolysed into activated caspase‐1 subsequently 6,7,11 .…”

Section: Introductionmentioning

confidence: 99%

“…Activated caspase‐1 then acted as a crucial enzyme to stimulate specific targets including interleukin‐1β (IL‐1β) and interleukin‐18 (IL‐18), which recruits pro‐inflammatory response in the initiation and progression of MIRI 6,7,11,12 . Thus, targeting pyroptosis‐related myocardial death may be a therapeutic approach for the treatment of MIRI 7,10,12 …”

Section: Introductionmentioning

confidence: 99%

“…Piperine (PIP) is a phenolic substance that found in black pepper and long pepper 13,14 . miRNAs function as highly conserved non‐coding RNAs and repress target mRNA via direct bonding to 3′UTR, thereby implicating in myocardial pyroptosis and I/R injury 10,15 . Previous studies have reported that PIP exerts pharmacological effects possible via miRNA‐dependent manners 16,17 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR‐383/RP105/AKT signalling pathway

Guo

Huang

Liu

et al. 2020

J Cellular Molecular Medi

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show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR‐383/RP105/AKT signalling pathway

Guo

Huang

Liu

et al. 2020

J Cellular Molecular Medi

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Sevoflurane exerts protection against myocardial ischemia–reperfusion injury and pyroptosis through the circular RNA PAN3/microRNA-29b-3p/stromal cell-derived factor 4 axis

Tan

et al. 2023

International Immunopharmacology

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Regulation of pyroptosis in cardiovascular pathologies: Role of noncoding RNAs

Gao

Chen

Wei

et al. 2021

Molecular Therapy - Nucleic Acids

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Cardiovascular disease (CVD) is one of the most important diseases endangering human life. The pathogenesis of CVDs is complex. Pyroptosis, which differs from traditional apoptosis and necrosis, is characterized by cell swelling until membrane rupture, resulting in the release of cell contents and activation of a strong inflammatory response. Recent studies have revealed that inflammation and pyroptosis play important roles in the progression of CVDs. Noncoding RNAs (ncRNAs) are considered promising biomarkers and potential therapeutic targets for the diagnosis and treatment of various diseases, including CVDs. Growing evidence has revealed that ncRNAs can mediate the transcriptional or posttranscriptional regulation of pyroptosis-related genes by participating in the pyroptosis regulatory network. The role and molecular mechanism of pyroptosis-regulating ncRNAs in cardiovascular pathologies are attracting increasing attention. Here, we summarize research progress on pyroptosis and the role of ncRNAs, particularly microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), in the regulation of pyroptosis in CVD pathologies. Identifying these disease-related ncRNAs is important for understanding the pathogenesis of CVDs and providing new targets and ideas for their prevention and treatment.Noncoding RNAs (ncRNAs) account for up to 98%-99% of the human genome and participate in regulating the expression of protein-coding genes. 10,11 The interaction between ncRNAs and protein-coding genes forms a highly complex RNA regulatory network. Abnormalities in ncRNAs are closely related to numerous diseases. Recent efforts to identify the molecular mechanisms underlying the pathogenesis of CVDs have revealed a significant regulatory role of ncRNAs in the occurrence and development of major CVDs, such as myocardial infarction, coronary heart disease, atrial fibrillation, atherosclerosis, cardiomyopathy, and heart failure. [12][13][14] The main classes of ncRNAs are microRNAs (miRNAs), long ncRNAs

show abstract

MiR-703 protects against hypoxia/reoxygenation-induced cardiomyocyte injury via inhibiting the NLRP3/caspase-1-mediated pyroptosis

Cited by 18 publications

References 22 publications

Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR‐383/RP105/AKT signalling pathway

Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR‐383/RP105/AKT signalling pathway

Sevoflurane exerts protection against myocardial ischemia–reperfusion injury and pyroptosis through the circular RNA PAN3/microRNA-29b-3p/stromal cell-derived factor 4 axis

Regulation of pyroptosis in cardiovascular pathologies: Role of noncoding RNAs

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