miR-644a is a tumor cell-intrinsic mediator of sex bias in glioblastoma
Ellen S. Hong,
Sabrina Z. Wang,
András K. Ponti
et al.
Abstract:Background: Biological sex is an important risk factor for glioblastoma (GBM), with males having a higher incidence and poorer prognosis. The mechanisms for this sex bias are thought to be both tumor intrinsic and tumor extrinsic. MicroRNAs (miRNAs), key post-transcriptional regulators of gene expression, have been previously linked to sex differences in various cell types and diseases, but their role in the sex bias of GBM remains unknown. Methods: We leveraged previously published paired miRNA and mRNA seque… Show more
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