miR-627-3p inhibits osteosarcoma cell proliferation and metastasis by targeting PTN

He, Ming; Shen, Peng; Qiu, Chuang; Wang, Jiashi

doi:10.18632/aging.102157

Cited by 28 publications

(26 citation statements)

References 23 publications

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“…Over the past decades, multiple genomic factors were revealed to be related to OS, including miRNAs [2], lncRNAs [3], and transcription factors [4]. For instance, miR-627-3p was reported to inhibit OS cell proliferation by reducing PTN [5], and miR-548d-3p was reported to inhibit OS by downregulating KRAS [6]. lncRNA TUG1 could promote OS cell metastasis by mediating HIF-1α [7] and AKT signaling [8].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218

Lin

Liu

Xiang

et al. 2020

BioMed Research International

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Circular RNAs (circRNAs) play a key role in regulating the tumorigenesis and development of human cancers, including osteosarcoma (OS). Of note, the molecular mechanism underlying the progression of OS has remained largely unclear. The present study identified that a novel circRNA circEIF4G2 was upregulated in OS tissues and cells. Moreover, we constructed a circEIF4G2-mediated ceRNA network and revealed that circEIF4G2 was involved in regulating multiple cancer pathways, such as the EGFR signaling pathway, the PI3K-Akt signaling pathway, and the ErbB signaling pathway. Loss-of-function assays showed that circEIF4G2 knockdown significantly suppressed OS cell proliferation, migration, and invasion. Mechanically, we found that circEIF4G2 could directly bind to miR-218, and miR-218 mediated the effect of circEIF4G2 knockdown on OS progression. In conclusion, the present study showed that circEIF4G2 could be a potential biomarker for OS.

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Section: Introductionmentioning

confidence: 99%

[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218

Lin

Liu

Xiang

et al. 2020

BioMed Research International

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“…The rs6983267 might indicate gain target of hsa-miR-6820-3p, hsa-miR-627-3p, hsa-miR-5190, hsa-miR-4276, hsa-miR-3164, while loss target of hsa-miR-519e-3p, hsa-miR-371a-3p, hsa-miR-33b-3p, hsa-miR-515-3p. Some of them involved in tumorigenesis in current literatures, the downregulation of hsa-miR-627-3p promote osteosarcoma cell proliferation and metastasis; 24 miR-33b-3p also altered the cisplatin sensitivity of cancer cells by impairing the DNA damage response; 25 miR-371a-3 currently reported biomarker for germ cell tumors (GCT), and clinical value of plasma miR-371a-3p level in chemotherapy naive GCT patients is a biomaker to initiate first line of chemotherapy and predict prognosis, 26 , 27 so the rs6983267 might regulate interaction between miR-371a-3 and lncRNA CCAT2 to alter GCT diagnosis and therapy sensitivity; miR-515-3p was markedly overexpressed in individuals with gastric carcinoma compared with that in normal gastric cells (NCs) and the surgery group ( P < 0.0001), and yielded an increase area under the curve (AUC) value with miR-515-3p in model construction. 28 The rs1456315 may bring gain target of hsa-miR-376a-2-5p and loss target of hsa-miR-3149, and hsa-mir-3149 have reported to play important role in DNA repair and immunity by inhibiting expression of ovarian tumor protease deubiquitinase 5 (OTUD5), as a member of the ovarian tumor protease family, 29 therefore rs1456315 and rs6983267 may influence binding between LncRNA and miRNA to modulate epigenetic process.…”

Section: Discussionmentioning

confidence: 99%

LncRNA PRNCR1 rs1456315 and CCAT2 rs6983267 Polymorphisms on 8q24 Associated with Lung Cancer

Yao

Xie

et al. 2021

IJGM

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Background Long noncoding RNA single nucleotide polymorphisms (lncRNA-SNPs) PCAT1 rs710886, PRNCR1 rs1456315 and CCAT2 rs6983267 on 8q24 region present generalizability in the susceptibility to multiple cancers, however, the influence of rs710886, rs1456315 and rs6983267 on lung cancer has not been assessed. The aim of this study was to investigate associations between three lncRNA-SNPs and lung cancer. Methods A case–control study was performed on 438 patients with lung cancer and 456 healthy controls in the Han population from southern China. The collected samples were genotyped by the TaqMan genotyping, and the association with clinical characteristics, including age, gender, drinking status, smoking status, pathological types and clinical stages were analyzed. And the SNP function prediction was based on lncRNASNP2, RNAfold and GTEx. Results The rs1456315 T allele increased the risk of lung cancer [OR=1.95, 95% CI (1.58–2.43), P =0.003] compared to the rs1456315 C allele, and rs1456315 significantly increased the risk of lung cancer in the dominant model [OR=1.86, 95% CI (1.16–3.00), P =0.002]. The rs6983267 G allele, compared with the T allele, increased the risk of lung cancer [OR=1.29, 95% CI (1.07–1.57), P =0.007], and rs6983267 was identified as a risk factor for lung cancer [OR=1.28, 95% CI (1.06–1.55), P =0.003] in the additive model. Both rs1456315 and rs6983267 demonstrated significance after adjusting for the smoking status, drinking status and age. The structure prediction found rs6983267 and rs1456315 influence the secondary structure of its lncRNA. The results from lncRNASNP2 indicated that rs6983267 and rs1456315 change gain/loss target of miRNAs. Conclusion PRNCR1 rs1456315 and CCAT2 rs6983267 on 8q24 region are significantly associated with lung cancer in the Han population of southern China and alter the potential biological function in bioinformatic analysis, and the results further extended generalism of the susceptibility of cancer-associated lncRNA-SNPs to lung cancer and underlying mechanism involved in lung cancer.

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“…Data from Chen et al indicated that overexpression of miR-548d-3p reduced osteosarcoma cells growth and migration in vitro by silencing KRAS [15]. Moreover, miR-627-3p and miR-506-3p have been reported to act as tumour suppressors in osteosarcoma by targeting PTN and RAB3D, respectively [16,17].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: miR-557 suppressed the malignant behaviours of osteosarcoma cells by reducing HOXB9 and deactivating the EMT process

Wang

2021

Artificial Cells, Nanomedicine, and Biotechnology

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MicroRNAs (miRNAs) are vital gene regulators, which play a profound role in the process of forming and developing many diseases, especially tumour. The study intends to excavate the potential regulatory mechanisms of miR-557 and its targeting gene Homeobox B9 (HOXB9) in osteosarcoma. GEO dataset on osteosarcoma was applied to detect the expression of miR-557 and HOXB9. Associations between miR-557 and HOXB9 were speculated by prediction software and verified by dual luciferase assay. Cell proliferation, colony formation and mobility were measured by cell counting kit-8, plate clone formation and transwell assays. Expression of mesenchymal transitions (MTs) related proteins was assessed by western blot analysis. Low expression of miR-557 was presented in osteosarcoma tissues and cell lines. Upregulation of miR-557 restrained osteosarcoma cells proliferation, movement and MT process. HOXB9, served as a target gene of miR-557, was highly expressed in osteosarcoma, and its high expression was associated with poor prognosis in patients with osteosarcoma. In addition, overexpression of HOXB9 attenuated the inhibitory effects of miR-557 on tumour progression by MT process. Overexpression of miR-557 suppressed the growth, metastasis and MT process of osteosarcoma cells by targeting HOXB9, affording novel molecular selection for targeted therapy of osteosarcoma.

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miR-627-3p inhibits osteosarcoma cell proliferation and metastasis by targeting PTN

Cited by 28 publications

References 23 publications

[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218

[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218

LncRNA PRNCR1 rs1456315 and CCAT2 rs6983267 Polymorphisms on 8q24 Associated with Lung Cancer

RETRACTED ARTICLE: miR-557 suppressed the malignant behaviours of osteosarcoma cells by reducing HOXB9 and deactivating the EMT process

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