MiR-590-3p Promotes the Phenotypic Switching of Vascular Smooth Muscle Cells by Targeting Lysyl Oxidase
Lei Wang,
Lin Zhang,
Li-kun Cui
et al.
Abstract:We investigated the clinical characteristics of patients with acute aortic dissection (AAD) and miR-590-3p levels in serum, tissue, and vascular smooth muscle cells (VSMCs). The effect of miR-590-3p on the VSMC phenotype was assessed, and the regulation of lysyl oxidase (LOX) by miR-590-3p was determined. C57BL/6 mice were used to investigate the incidence of AAD and effects of miR-590-3p on AAD. MiR-590-3p levels were measured in the aortae of mice, and hematoxylin and eosin (H&E) staining and Masson stai… Show more
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