miR-582 Suppresses the Proliferation of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Cells and Protects Them From Natural Killer Cell-Mediated Cytotoxicity

Li, Xinxin; Zhang, Yufei; He, Fei; Gao, Dan; Che, Bo; Cao, Xinsheng; Huang, Shuheng; Zheng, Min; Han, Hua

doi:10.3389/fimmu.2022.853094

Cited by 3 publications

(2 citation statements)

References 46 publications

(57 reference statements)

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“…A study on leukemic cells in 5 patients with B-cell precursor ALL (BCP-ALL) also showed that microRNA582 inhibits the cytotoxic effects of NK cells on leukemic cells by inducing the CD276 (B7-H3) checkpoint. Therefore, it is suggested that blockade of CD276 or its ligand on NK cells may be a potential therapeutic approach in leukemia [ 90 ]. In addition to the discussed inhibitory checkpoints, Rothfelder et al .…”

Section: Exhausted Nk Cells and Leukemiamentioning

confidence: 99%

The role of exhausted natural killer cells in the immunopathogenesis and treatment of leukemia

Barshidi,

Ardeshiri,

Ebrahimi

et al. 2024

Cell Commun Signal

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The immune responses to cancer cells involve both innate and acquired immune cells. In the meantime, the most attention has been drawn to the adaptive immune cells, especially T cells, while, it is now well known that the innate immune cells, especially natural killer (NK) cells, play a vital role in defending against malignancies. While the immune cells are trying to eliminate malignant cells, cancer cells try to prevent the function of these cells and suppress immune responses. The suppression of NK cells in various cancers can lead to the induction of an exhausted phenotype in NK cells, which will impair their function. Recent studies have shown that the occurrence of this phenotype in various types of leukemic malignancies can affect the prognosis of the disease, and targeting these cells may be considered a new immunotherapy method in the treatment of leukemia. Therefore, a detailed study of exhausted NK cells in leukemic diseases can help both to understand the mechanisms of leukemia progression and to design new treatment methods by creating a deeper understanding of these cells. Here, we will comprehensively review the immunobiology of exhausted NK cells and their role in various leukemic malignancies.

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Section: Exhausted Nk Cells and Leukemiamentioning

confidence: 99%

The role of exhausted natural killer cells in the immunopathogenesis and treatment of leukemia

Barshidi,

Ardeshiri,

Ebrahimi

et al. 2024

Cell Commun Signal

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“…Li et al [38] observed that miR-582 overexpression increased NK cell-mediated cytotoxicity with B-cell precursor acute lymphoblastic leukemia cells upregulating the expression of B7-H3 (CD276), which is a newly discovered member of the B7 family that could promote T cell activation [61,62].…”

Section: Mirnas That Modulate Response To Icismentioning

confidence: 99%

miRNAs Related to Immune Checkpoint Inhibitor Response: A Systematic Review

García-Giménez,

Saadi,

Ortega

et al. 2024

IJMS

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The advent of immune checkpoint inhibitors (ICIs) has represented a breakthrough in the treatment of many cancers, although a high number of patients fail to respond to ICIs, which is partially due to the ability of tumor cells to evade immune system surveillance. Non-coding microRNAs (miRNAs) have been shown to modulate the immune evasion of tumor cells, and there is thus growing interest in elucidating whether these miRNAs could be targetable or proposed as novel biomarkers for prognosis and treatment response to ICIs. We therefore performed an extensive literature analysis to evaluate the clinical utility of miRNAs with a confirmed direct relationship with treatment response to ICIs. As a result of this systematic review, we have stratified the miRNA landscape into (i) miRNAs whose levels directly modulate response to ICIs, (ii) miRNAs whose expression is modulated by ICIs, and (iii) miRNAs that directly elicit toxic effects or participate in immune-related adverse events (irAEs) caused by ICIs.

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Advancements in the Regulatory Role of microRNAs in Childhood Acute Lymphoblastic Leukemia: Mechanisms and Clinical Implications

Deng

2024

Technol Cancer Res Treat

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microRNAs (miRNAs), tiny, non-coding RNA molecules, fine-tune the expression of target genes through interacting with mRNAs. These miRNAs are involved in a wide range of biological processes, encompassing cell division, death, blood cell production, and tumor development. When these miRNAs become dysfunctional, they can promote the invasion and spread of cancer cells in various human malignancies, including leukemia. Acute lymphoblastic leukemia (ALL), the preeminent malignancy affecting children, is a blood cancer marked by the uncontrollable growth of immature lymphoid cells that displace healthy blood precursors in the bone marrow. Despite a decline in ALL mortality rates over the past two decades, a significant proportion of deaths still results from a lack of effective diagnostic and prognostic markers that can guide treatment decisions and overcome drug resistance. The analysis of miRNA expression patterns in ALL could lead to more precise disease classification, earlier diagnosis, and better prognostic outcomes in the near future. The connection between miRNA dysfunction and the biology of ALL suggests that these molecules could represent promising therapeutic targets. Therefore, this review delves into the regulatory mechanisms of miRNAs in pediatric ALL, exploring how miRNA-based diagnostic, prognostic, and therapeutic strategies offer unique advantages and hold promise for clinical applications.

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miR-582 Suppresses the Proliferation of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Cells and Protects Them From Natural Killer Cell-Mediated Cytotoxicity

Cited by 3 publications

References 46 publications

The role of exhausted natural killer cells in the immunopathogenesis and treatment of leukemia

The role of exhausted natural killer cells in the immunopathogenesis and treatment of leukemia

miRNAs Related to Immune Checkpoint Inhibitor Response: A Systematic Review

Advancements in the Regulatory Role of microRNAs in Childhood Acute Lymphoblastic Leukemia: Mechanisms and Clinical Implications

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