miR-552 promotes the proliferation and metastasis of cervical cancer cells through targeting MUC15 pathway

Abstract

Accumulating evidence shows that microRNAs (miRNAs) play key roles in tumorigenesis, progression, recurrence and drug resistance of malignant tumors. The tumor-promoting role of miR-552 has been evidenced in multiple tumors. Yet, the relevance of miR-552 in cervical cancer remains undetermined. This study aimed to investigate the role of miR-552 in cervical cancer proliferation and metastasis. Herein, we for first found that miR-552 expression was upregulated in cervical cancer tissues compared with their normal controls. Functional assays revealed that miR-552 promoted the proliferation and metastasis of cervical cancer cells. Mechanically, bioinformatics and luciferase reporter analysis identified MUC15 as a direct target of miR-552. Reduced MUC15 expression was detected in cervical cancer, and MUC15 overexpression exhibited a tumor-suppressive effect. MUC15 restoration partially abolished the discrepancy of growth and metastasis capacity between miR-552 overexpression cervical cancer cells and control cells. Taken together, these data demonstrate that miR-552 acts as a potential oncogene miRNA in cervical cancer, which exerts its function through targeting MUC15.

Evaluation and Application of Drug Resistance by Biomarkers in the Clinical Treatment of Liver Cancer

“…The MUC15/c-Met/PI3K/AKT/SOX2 axis determines the responses of hepatoma cells to lenvatinib treatment, as supported by the observation that MUC15 overexpression abrogates lenvatinib resistance [ 160 ]. In addition, miR-552 promotes the proliferation and metastasis of cervical cancer cells by targeting the MUC15 pathway [ 161 ].…”

MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation

“…Fold Change Function Reference hsa-miR-495-5p >10 Promotes Th2 differentiation in allergic rhinitis, as a tumor suppressor [23] hsa-miR-628-5p >10 Inhibits osteoblast differentiation via RUNX2 [24] hsa-miR-361-3p >10 Suppresses proliferation, invasion inhibited cells invasive and proliferative abilities, and cell lines invasion and proliferation [25,26] hsa-miR-875-5p >10 Promotes cellular apoptosis and proliferation [27] hsa-miR-509-3p >10 Tumor suppressor [28,29] hsa-miR-518b hsa-miR-23c <10 Inhibits cell proliferation and induces apoptosis of hepatocellular carcinoma cells; cell growth arrest and apoptosis. [57] hsa-miR-383-5p <10 Oxidative stress and inflammation-related factors [58] hsa-miR-574-5p <10 Promotes the differentiation of human cardiac fibroblasts [59] hsa-miR-151a-5p <10 Regulation of cellular respiration and ATP production through targeting Cytb [60] hsa-miR-514a-3p <10 Attenuates proliferation and increases chemoresistance [61] hsa-miR-136-3p <10 Promotes apoptosis in gastric cancer cells [62] hsa-miR-1-3p <10 Inflammation; regulator of heart adaption after ischemia or ischemic stress [63] hsa-miR-18a-3p <10 Downregulated in aging cells; induces the apoptosis of colon cancer cells [64] hsa-miR-502-5p <10 Enhances early apoptosis and inhibits proliferation of breast cancer cells [65] hsa-miR-451a <10 Apoptosis; inhibits autophagy [66] hsa-miR-19b-1-5p <10 Linked to oxidative stress, inflammation, and atherosclerosis [67] hsa-miR-873-5p <0.1 Tumor suppressor in thyroid cancer by inhibiting the proliferation, migration, and invasion of the cancer cells [68] hsa-miR-212-5p <0.1 Promotes cancer cell apoptosis and suppresses cancer cell proliferation and invasion [69] hsa-miR-552-5p <0.1 Tumorigenesis; progression [70] hsa-let-7a-3p <0.1 Linked to oxidative stress, inflammation, and atherosclerosis [71] hsa-miR-495-3p <0.1 Regulates proliferation, apoptosis, migration, and invasion in metastatic prostate cancer cells. [68] Table 1.…”