miR-524-5p inhibits angiogenesis through targeting WNK1 in colon cancer cells

Li, Xiang; Li, Zitao; Zhu, Ye; Zhu, Li; Yao, Lihong; Zhang, Lamei; Yuan, Lin; Shang, Yang; Liu, Jianting; Li, Caijuan

doi:10.1152/ajpgi.00369.2019

Cited by 19 publications

(18 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…98 pancreatic cancer samples, although there was high expression of AGTR1 in this cancer. Pearson correlation analysis showed an inverse relationship between AGTR1 and miR-410 expression.…”

mentioning

confidence: 73%

Angiogenesis-related non-coding RNAs and gastrointestinal cancer

Razavi

Asgarpour

Mahjoubin‐Tehran

et al. 2021

Molecular Therapy - Oncolytics

View full text Add to dashboard Cite

Gastrointestinal (GI) cancers are among the main reasons for cancer death globally. The deadliest types of GI cancer include colon, stomach, and liver cancers. Multiple lines of evidence have shown that angiogenesis has a key role in the growth and metastasis of all GI tumors. Abnormal angiogenesis also has a critical role in many non-malignant diseases. Therefore, angiogenesis is considered to be an important target for improved cancer treatment. Despite much research, the mechanisms governing angiogenesis are not completely understood. Recently, it has been shown that angiogenesis-related non-coding RNAs (ncRNAs) could affect the development of angiogenesis in cancer cells and tumors. The broad family of ncRNAs, which include long non-coding RNAs, microRNAs, and circular RNAs, are related to the development, promotion, and metastasis of GI cancers, especially in angiogenesis. This review discusses the role of ncRNAs in mediating angiogenesis in various types of GI cancers and looks forward to the introduction of mimetics and antagonists as possible therapeutic agents.

show abstract

“…98 pancreatic cancer samples, although there was high expression of AGTR1 in this cancer. Pearson correlation analysis showed an inverse relationship between AGTR1 and miR-410 expression.…”

mentioning

confidence: 73%

Angiogenesis-related non-coding RNAs and gastrointestinal cancer

Razavi

Asgarpour

Mahjoubin‐Tehran

et al. 2021

Molecular Therapy - Oncolytics

View full text Add to dashboard Cite

show abstract

“…Those results indicated that the role of miRNA-93 could be attributed to a reduction in WNK1 expression (21). miRNA-524-5p agomir treatment was also shown to inhibit the angiogenesis of colon cancer through the down- regulation of WNK1 expression (52). It appears that 3phosphoinositide-dependent protein kinase 1 (PDK1)-WNK1 signaling could be a potential therapeutic target in the treatment of HBV-related liver cancer (53).…”

Section: Discussionmentioning

confidence: 98%

Prognostic and Clinical Implications of WNK Lysine Deficient Protein Kinase 1 Expression in Patients With Hepatocellular Carcinoma

Chang

Yeh

et al. 2020

In Vivo

View full text Add to dashboard Cite

Background/Aim: Hepatocellular carcinoma (HCC) is a particularly malignant form of cancer prevalent throughout the world; however, there is a pressing need for HCC biomarkers to facilitate prognosis and risk assessment. Patients and Methods: This paper reports on the potential prognostic value of WNK lysine deficient protein kinase 1 (WNK1) in cases of HCC. We analyzed the expression of WNK1 at the mRNA level using omics data from the UALCAN database. We then verified our findings through the immunohistochemical (IHC) staining of various human cancer tissue as well as 59 HCC samples paired with corresponding normal tissues. The prognostic value of mRNA or protein expression by WNK1 was evaluated using the Kaplan-Meier method. Results: Initial screening results revealed significantly higher WNK1 expression levels in HCC tissue compared to normal tissue. Verification using the paired HCC samples confirmed that the expression of WNK1 was indeed significantly higher in HCC tissue samples than in adjacent normal tissues. High WNK1 expression levels were significantly correlated with clinicopathological variables, including gender and histologic grade. Kaplan-Meier survival analysis revealed that high WNK1 expression levels were associated with poor HCC prognosis. Finally, univariate and multivariate analysis identified WNK1 as a prognostic factor for TNM stage in cases of HCC. Conclusion: In summary, WNK1 is overexpressed at the mRNA and protein levels, and correlated with poor prognosis. Thus, WNK1 expression could potentially be used as a biomarker in HCC prognosis. Hepatocellular carcinoma (HCC) is responsible for an enormous number of cancer-related deaths, particularly in sub-Saharan Africa and Southeast Asia (1, 2). HCC is among the deadliest forms of cancer, and the treatment of HCC has been well demonstrated in multiple series, with an overall 5year survival rate between 33% and 55% (3). The most common risk factors include infections with hepatitis B virus (HBV) or hepatitis C virus (HCV), chronic exposure to aflatoxin B (AFB1), excessive alcohol consumption (EAC), non-alcoholic steatohepatitis (NASH), and metabolic syndrome (METS). HCC commonly progresses from chronic liver inflammation and cirrhosis, which eventually trigger the formation of liver tumors (4, 5). The fact that the early symptoms of HCC are not obvious means that at the time of diagnosis, most patients are in the middle or late stages of the disease (i.e., beyond the window for surgery). Note that 50% of patients who undergo radical surgical 2631 This article is freely accessible online.

show abstract

“…But there was still no report about miR-524-5p in laryngocarcinoma. MiR-524-5p was reported to act as a cancer suppressor gene in multiple tumors, including gastric cancer [ 34 ], papillary thyroid cancer [ 35 ], melanoma [ 36 ], breast cancer [ 37 ], colorectal carcinoma [ 38 ], osteosarcoma [ 39 ]. In this study, we found that miR-524-5p expression was reduced in laryngocarcinoma tissues and cell lines.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells

Zhang

Wang

Cui

2021

Aging

View full text Add to dashboard Cite

Long noncoding RNA nuclear paraspeckle assembly transcript 1 (lncRNA NEAT1) is abnormally expressed in numerous tumors and functions as an oncogene, but the role of NEAT1 in laryngocarcinoma is largely unknown. Our study validated that NEAT1 expression was markedly upregulated in laryngocarcinoma tissues and cells. Downregulation of NEAT1 dramatically suppressed cell proliferation and invasion through inhibiting miR-524-5p expression. Additionally, NEAT1 overexpression promoted cell growth and metastasis, while overexpression of miR-524-5p could reverse the effect. NEAT1 increased the expression of histone deacetylase 1 gene (HDAC1) via sponging miR-524-5p. Mechanistically, overexpression of HDAC1 recovered the cancer-inhibiting effects of miR-524-5p mimic or NEAT1 silence by deacetylation of tensin homolog deleted on chromosome ten (PTEN) and inhibiting AKT signal pathway. Moreover, in vivo experiments indicated that silence of NEAT1 signally suppressed tumor growth. Taken together, knockdown of NEAT1 suppressed laryngocarcinoma cell growth and metastasis by miR-524-5p/HDAC1/PTEN/AKT signal pathway, which provided a potential therapeutic target for laryngocarcinoma.

show abstract

miR-524-5p inhibits angiogenesis through targeting WNK1 in colon cancer cells

Cited by 19 publications

References 29 publications

Angiogenesis-related non-coding RNAs and gastrointestinal cancer

Angiogenesis-related non-coding RNAs and gastrointestinal cancer

Prognostic and Clinical Implications of WNK Lysine Deficient Protein Kinase 1 Expression in Patients With Hepatocellular Carcinoma

Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells

Contact Info

Product

Resources

About