MiR-506-3p suppresses the proliferation of ovarian cancer cells by negatively regulating the expression of MTMR6

Wang, Yuan; Lei, Xia; Gao, Chengying; Xue, Yifeng; Li, Xin; Wang, Haiying; Feng, Yan

doi:10.1007/s12038-019-9952-9

Cited by 25 publications

(20 citation statements)

References 38 publications

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“…On the other hand, it has been shown that the downregulation of hsa-miR-513c promotes the proliferation and invasiveness of neuroblastoma and glioma cells [38,39]. Similar to that downregulation of hsa-miR-506, leads to increased proliferation, invasiveness, and epithelial to mesenchymal transition in breast gastric and ovarian cancer [40][41][42]. Moreover, in vitro studies showed that overexpression of this miRNA is responsible for the increased sensitivity of colorectal cancer cells to chemotherapy [42].…”

Section: Discussionmentioning

confidence: 86%

The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression

Wróblewska

Lach

Ustaszewski

et al. 2020

Genes

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Uveal melanoma (UM) is the most common primary tumor of the eye diagnosed in adults, associated with a high risk of metastasis and thereby, poor prognosis. Among known risk factors for the development of metastatic disease is the loss of BAP1 expression and chromosome 3 monosomy in the primary tumor. However, the expression levels of specific micro RNAs (miRNA) in tumor tissue may also serve as a valuable marker for determining the risk of metastatic disease in patients with primary uveal melanoma. In our study, we analyzed the miRNA expression data of cases selected from The Cancer Genome Atlas study on uveal melanoma, and determined a panel of 15 miRNAs differentially expressed between patients with primary and metastatic disease. Next, 6 miRNAs were validated on a group of 46 tumor samples from primary and metastatic patients. We have shown, that expression of hsa-miR-592, hsa-miR-346, and hsa-miR-1247 was significantly increased, while hsa-miR-506 and hsa-miR-513c were decreased in the tumors of patients with metastatic disease. Hsa-miR-196b expression did not differ between the two subgroups, however, we showed significant correlation with BAP1 expression. Moreover, hsa-miR-592 also showed correlation with monosomy 3 tumors. Gene ontology analysis revealed involvement of those miRNAs with cellular processes mediating the metastatic process. Our results showed that miRNAs play an important role in the deregulation of several oncogenic pathways in UM and can, thereby, promote metastatic spread to distant organs. Moreover, differentially expressed miRNAs may be used as an interesting biomarker for the assessment of metastatic risk in uveal melanoma patients.

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Section: Discussionmentioning

confidence: 86%

The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression

Wróblewska

Lach

Ustaszewski

et al. 2020

Genes

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“…Similar to lncRNA, the abnormal expression of miRNAs is closely interrelated to the development of tumors and features prominently in biological activities, including cell differentiation, stress response, proliferation, apoptosis, migration, and so on [ 9 ]. Mounting evidence shows that miRNA can affect the growth and metastasis of OC cells [ 3 , 10 , 11 ]. Previous studies depict that miR-577 expression is abnormally reduced in diverse human malignancies, such as gastric cancer, breast cancer and glioma, suggesting that miR-577 is a tumor suppressor [ 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

LINC01094/miR-577 axis regulates the progression of ovarian cancer

Zhang

Sun

et al. 2020

J Ovarian Res

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Background Long intergenic non-coding RNA 01094 (LINC01094) is probably a novel regulator in cancer biology. This study aimed to probe into the function and mechanism of LINC01094 in ovarian cancer (OC). Methods Quantitative real-time polymerase chain reaction (qRT-PCR) assay was utilized to measure LINC01094 and miR-577 expressions in OC tissues and cell lines. Western blot was used to examine the expressions of epithelial-mesenchymal transition (EMT)-related proteins, β-catenin, c-Myc and cyclin D1. Cell counting kit-8 (CCK-8) and Transwell assays were used to detect the proliferation, migration and invasion of SKOV3 and 3AO cells, respectively. Eventually, dual-luciferase reporter gene assay was employed to detect the regulatory relationship between miR-577 and LINC01094. Results LINC01094 expression was elevated in OC tissues and cell lines. High LINC01094 expression was associated with higher FIGO stage, lymph node metastasis and the shorter overall survival rate in patients with OC. Meanwhile, LINC01094 knockdown inhibited OC cell proliferation, migration, invasion and EMT. In addition, miR-577 was demonstrated to be a direct downstream target of LINC01094 in OC and inhibition of miR-577 reversed the biological effects of LINC01094 knockdown on OC cells. Additionally, LINC01094 / miR-577 axis regulated the expressions of β-catenin, c-Myc and cyclin D1 in OC cells. Conclusion LINC01094 promotes the proliferation, migration, invasion and EMT of OC cells by adsorbing miR-577.

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“…The results indicated that miR-506-3p was a target of HOXA11-AS and negatively regulated by HOXA11-AS. miR-506-3p has been identified to play tumor suppressive role in several human cancers, such as ovarian cancer and retinoblastoma ( 35 , 36 ). For example, miR-506-3p has been demonstrated to suppress tumor progression in prostate cancer and pancreatic cancer ( 37 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA HOXA11‑AS accelerates cell proliferation and epithelial‑mesenchymal transition in hepatocellular carcinoma by modulating the miR‑506‑3p/Slug axis

et al. 2020

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Hepatocellular carcinoma (Hcc) is an aggressively malignant type of cancer with a complex pathogenesis. Multiple studies have identified that lncRNA HOXA11-AS is involved in the development of Hcc. Nevertheless, the pathological mechanisms of HOXA11-AS in the development of Hcc require further investigation. In the present study, the role and underlying mechanisms of HOXA11-AS in HCC were examined. RT-qPCR revealed that HOXA11-AS expression was increased, while that of miR-506-3p was decreased in Hcc tissues and cells compared with that in adjacent non-tumor tissues and normal hepatic cells. dual-luciferase reporter assay and RNA pull-down assay indicated that HOXA11-AS directly interacted with miR-506-3p. miR-506-3p downregulation reversed the inhibitory effects of HOXA11-AS deletion on cell proliferation, invasion and epithelial-mesenchymal transition (EMT), as shown by ccK-8 and Transwell assays, as well as western blot analysis. Bioinformatics analysis and dual-luciferase reporter assay indicated that Slug was a target gene of miR-506-3p. The overexpression of Slug reversed the effects of HOXA11-AS deletion on the viability, invasion and the EMT of Hcc cells. Taken together, the present study demonstrates that HOXA11-AS functions as an oncogene to promote the progression of Hcc via the miR-506-3p/Slug axis, providing a therapeutic target for patients with Hcc.

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MiR-506-3p suppresses the proliferation of ovarian cancer cells by negatively regulating the expression of MTMR6

Cited by 25 publications

References 38 publications

The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression

The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression

LINC01094/miR-577 axis regulates the progression of ovarian cancer

Long non‑coding RNA HOXA11‑AS accelerates cell proliferation and epithelial‑mesenchymal transition in hepatocellular carcinoma by modulating the miR‑506‑3p/Slug axis

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