Abstract:Background:There is an increasing attention on miRNAs because of their
functional effect on polarization of CD4+ T cells. This study explores
the mechanism of miR-493-5p regulating Th9 cell differentiation in
allergic asthma. Methods: The allergic airway inflammation is induced by
Ovalbumin(OVA)in mice. CD4+ T cells from normal mice are cultured under
Th9 cell conditions. IL-9 levels in mice and CD4+T cells are analyzed by
RT-qPCR, ELISA, flow cytometry and western blot. The miR-493-5p levels
in mice and cells… Show more
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