miR-483-3p targets FGFR2 to inhibit cardiomyocyte pyroptosis NLRP3/Caspase-1/GSDMD signaling axis and reduce myocardial fibrosis
Xiangwei Lv,
Liqin Chen,
Zifeng He
et al.
Abstract:Purpose
In this study, the role of miR-483-3p in reducing myocardial fibrosis (MF) is investigated and the underlying molecular mechanism is further explored.
Methods
Firstly, six SD rats were randomly divided into sham surgery (Sham) group and model (ISO) group, and high-throughput miRNAs sequencing technology was used to sequence MF model rats. Forty male SD rats were randomly divided into Sham group, ISO group, blank transfection (AAV-NC) group, and overexpression (AAV-miR-483-3p) group, with 10 rats in e… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.