miR-4739/ITGA10/PI3K signaling regulates differentiation and apoptosis of osteoblast

Song, Yuanlin; Meng, Zhen; Zhang, Shanshan; Li, Nianguo; Hu, Wei; Li, Hong

doi:10.1016/j.reth.2022.08.002

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…Regulation of maternal insulin resistance, T-cell activity promotion, and metastasis inhibition in cancers [240] downregulated: blood plasma-derived EVs [153] miR-4286 Insulin signaling [247], metastasis progression in cancer [248][249][250] and apoptosis regulation [251] downregulated: CSF exosomes and blood plasma-derived EVs [145,149,150]; upregulated: serum [155] miR-4505 HSPA12B Tumorigenesis [252] vascular function [253] upregulated: blood plasma-derived EVs [153] miR-4507 TP53; PI3K-AKT signaling Cell proliferation and migration in lung cancer [254] downregulated: blood plasma-derived EVs [153] miR-4508 125 predicted in miRDB [234] Potential involvement in pulmonary fibrosis through an unknown mechanism [255] downregulated: blood plasma-derived EVs [153] miR-4646-5p ABHD16A; PHD3; PHD3/HIF1A signaling Ubiquitination and cell proliferation and invasion regulation [256,257] downregulated: blood plasma-derived EVs [153] miR-4674 p38k Angiogenesis regulation [258] downregulated: blood plasma-derived EVs [153] miR-4687-5p ATP10D, THRSP Involved in polycystic ovary syndrome [259] downregulated: blood plasma-derived EVs [153] miR-4688 not yet studied miRNA sponge and cancer progression [260] upregulated blood plasma-derived EVs [153] miR-4700-5p not yet studied not yet studied upregulated blood plasma-derived EVs [153] miR-4736 AR Inflammatory response regulation [261] upregulated blood plasma-derived EVs [153] miR-4739 BMP-7; ITGA10/PI3K signaling Apoptosis and differentiation regulation [262] upregulated blood plasma-derived EVs [153] miR-4745-5p SIRT6/PCSk9 signaling sensibility to anesthetics regulatio...…”

Section: Stat3 Mmp2 Egfr/akt2/ccnd1 Signalingmentioning

confidence: 99%

Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives

Afonso

Cavaleiro

Valero

et al. 2023

Cells

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Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargo through the secretion of EVs, even in distant tissues. Importantly, owing to their nature and composition, EVs’ formation and cargo can be exploited for better comprehension of this elusive disease and identification of novel biomarkers, as well as for potential therapeutic applications, such as those based on stem cell-derived exosomes. This review highlights recent advances in the identification of the role of EVs in ALS etiopathology and how EVs can be promising new therapeutic strategies.

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Section: Stat3 Mmp2 Egfr/akt2/ccnd1 Signalingmentioning

confidence: 99%

Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives

Afonso

Cavaleiro

Valero

et al. 2023

Cells

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Keratinocytes drive the epithelial hyperplasia key to sea lice resistance in coho salmon

Salisbury,

Daniels,

Monaghan

et al. 2024

BMC Biol

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Background Salmonid species have followed markedly divergent evolutionary trajectories in their interactions with sea lice. While sea lice parasitism poses significant economic, environmental, and animal welfare challenges for Atlantic salmon (Salmo salar) aquaculture, coho salmon (Oncorhynchus kisutch) exhibit near-complete resistance to sea lice, achieved through a potent epithelial hyperplasia response leading to rapid louse detachment. The molecular mechanisms underlying these divergent responses to sea lice are unknown. Results We characterized the cellular and molecular responses of Atlantic salmon and coho salmon to sea lice using single-nuclei RNA sequencing. Juvenile fish were exposed to copepodid sea lice (Lepeophtheirus salmonis), and lice-attached pelvic fin and skin samples were collected 12 h, 24 h, 36 h, 48 h, and 60 h after exposure, along with control samples. Comparative analysis of control and treatment samples revealed an immune and wound-healing response that was common to both species, but attenuated in Atlantic salmon, potentially reflecting greater sea louse immunomodulation. Our results revealed unique but complementary roles of three layers of keratinocytes in the epithelial hyperplasia response leading to rapid sea lice rejection in coho salmon. Our results suggest that basal keratinocytes direct the expansion and mobility of intermediate and, especially, superficial keratinocytes, which eventually encapsulate the parasite. Conclusions Our results highlight the key role of keratinocytes in coho salmon’s sea lice resistance and the diverged biological response of the two salmonid host species when interacting with this parasite. This study has identified key pathways and candidate genes that could be manipulated using various biotechnological solutions to improve Atlantic salmon sea lice resistance.

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Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives

Afonso¹,

Cavaleiro²,

Valero³

et al. 2023

Preprint

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Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease, char-acterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease distinguished by high patient-to-patient heterogeneity, making its study arduous and complex. Extracellular vesicles (EVs) emerged as an important player in ALS development. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargos through the secretion of EVs, even at far distant tissues. Importantly, due to their nature and composition, EVs’ formation and cargo can be exploited for the better comprehension of this elusive disease and identification of novel biomarkers, as well as for potential therapeutic applications, such as those based on stem cell-derived exosomes. This review highlights the recent advances in the identification of the role of EVs in ALS etiopathology and how EVs can be promising new approaches for therapeutic strategies.

show abstract

miR-4739/ITGA10/PI3K signaling regulates differentiation and apoptosis of osteoblast

Cited by 5 publications

References 37 publications

Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives

Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives

Keratinocytes drive the epithelial hyperplasia key to sea lice resistance in coho salmon

Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives

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