miR-449a ameliorates acute rejection after liver transplantation via targeting procollagen-lysine1,2-oxoglutarate5-dioxygenase 1 in macrophages

Cao, Zhen-Rui; Zheng, Wei-Xiong; Jiang, Yuxin; Chai, Hao; Gong, Junhua; Zhao, Minjie; Yan, Ping; Liu, Yanyao; Liu, Xiaoya; Huang, Zuotian; Yang, Hang; Peng, Dadi; Zong, Kezhen; Wu, Zhongjun

doi:10.1016/j.ajt.2022.12.009

Cited by 1 publication

(1 citation statement)

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“…In the in vivo experiment of acute rejection model, adeno-associated virus-mediated expression of FGL2 (AAV-FGL2) effectively mitigates acute rejection ( Pan et al, 2018 ). Recently, it has been discovered that miR-449a can directly target PLOD1 mRNA and inhibit the NF-κB signaling pathway, thereby suppressing M1 polarization of Kupffer cells ( Cao et al, 2023 ). Additionally, miR-505-5p induces M2 polarization of macrophages through the MyD88/TRAF6 axis to mitigate acute rejection following liver transplantation ( Chai et al, 2022 ).…”

Section: The Role Of Different Functions Of Kupffer Cells In the Esta...mentioning

confidence: 99%

Role of Kupffer cells in tolerance induction after liver transplantation

Zheng

Yang

Jiang

et al. 2023

Front. Cell Dev. Biol.

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Currently, liver transplantation has reached a level of maturity where it is considered an effective treatment for end-stage liver disease and can significantly prolong the survival time of patients. However, acute and chronic rejection remain major obstacles to its efficacy. Although long-term use of immunosuppressants can prevent rejection, it is associated with serious side effects and significant economic burden for patients. Therefore, the investigation of induced immune tolerance holds crucial theoretical significance and socio-economic value. In fact, the establishment of immune tolerance in liver transplantation is intricately linked to the unique innate immune system of the liver. Kupffer cells, as a crucial component of this system, play a pivotal role in maintaining the delicate balance between inflammatory response and immune tolerance following liver transplantation. The important roles of different functions of Kupffer cells, such as phagocytosis, cell polarization, antigen presentation and cell membrane proteins, in the establishment of immune tolerance after transplantation is comprehensively summarized in this paper. Providing theoretical basis for further study and clinical application of Kupffer cells in liver transplantation.

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Section: The Role Of Different Functions Of Kupffer Cells In the Esta...mentioning

confidence: 99%