MiR-4484 Acts as a Potential Saliva Biomarker for Early Detection of Peri-implantitis

The role of miRNAs in titanium implants-molecular and pathophysiological mechanisms

“…Indeed, the early diagnosis of peri-implantitis is of great importance for the successful treatment and maintenance of peri-implant tissues in healthy status 40 . Urvasizoglu et al (2021) collected saliva samples from patients with titanium-aluminum-vanadium dental implants who had peri-implantitis and identified possible biomarkers for peri-implantitis 41 . They confirmed through qRT-PCR the deregulation of specific types of miRNAs ending up to the fact that that miR-4484 might be used as an early diagnosis biomarker for this condition 41 .…”

“…Urvasizoglu et al (2021) collected saliva samples from patients with titanium-aluminum-vanadium dental implants who had peri-implantitis and identified possible biomarkers for peri-implantitis 41 . They confirmed through qRT-PCR the deregulation of specific types of miRNAs ending up to the fact that that miR-4484 might be used as an early diagnosis biomarker for this condition 41 . On the other hand, based on the results of a systematic review which compared the concentration levels of certain biomarkers like cytocins (IL-1b, IL-6 and IL-10), antioxidants, urate, ascorbate between healthy and peri-implant tissues, there was no clear answer whether biomarkers can be used predictably in this direction 42 .…”